Detection of statistically significant network changes in complex biological networks by Raghvendra Mall (581171)

“…<h3>Background</h3><p dir="ltr">Biological networks contribute effectively to unveil the complex structure of molecular interactions and to discover driver genes especially in cancer context. It can happen that due to gene mutations, as for example when cancer progresses, the gene expression network undergoes some amount of localized re-wiring. …”

Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases by Mazhar Pasha (11197767)

“…Studies demonstrate that the upregulation of Sestrin2 under conditions of oxidative stress augments autophagy-directed degradation of Kelch-like ECH-associated protein 1 (Keap1), which targets and breaks down nuclear erythroid-related factor 2 (Nrf2), a key regulator of various antioxidant genes. …”

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes by Noura Aldous (15429873)

“…Pathway analysis and miRNA target genes identification was performed using Ingenuity Pathway Analysis (IPA) software. …”

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes by Noura Aldous (15429873)

“…RNA sequencing analysis demonstrated significant reduction in the mRNA expression of genes involved in the development and function of exocrine and endocrine pancreas. …”

Genetic evaluation of cardiomyopathies in Qatar identifies enrichment of pathogenic sarcomere gene variants and possible founder disease mutations in the Arabs by Kholoud N. Al‐Shafai (18459009)

“…In DCM, 56 putative DCM genes were analyzed. Eight percent of DCM cases had putative pathogenic variants for DCM, in the TTN gene while 70% of cases had variants of uncertain significance, in the analyzed DCM genes, that will need further pathogenicity assessment. …”

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 by Olfa Khalifa (10914452)

“…</p> <p>Results: Treatment with 200nM Ex-4 for 3h decreased the OA-induced lipid buildup significantly (p<0.05). Concurrently, Ex-4 significantly lowered the expression levels of De novo lipogenesis genes such as SREBP-1, SCD-1and ACC. …”

Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis by Shilpa Kuttikrishnan (3520079)

“…Interestingly <em>BUB1B</em> was found to be significantly downregulated (logFC -2.60, adjusted p = 0.001) in the treated cell line with the highest connectivity score among cancer genes. …”

Terrestrial Biodiversity Preservation in Qatar's Gene Bank by Maryam S. Al-Qahtani (23752884)

“…<p dir="ltr">Qatar's National Gene Bank has implemented a comprehensive biodiversity conservation program from 2012 to preserve terrestrial plant genetic resources. …”

The combinatory effects of diet and exercise on BDNF gene expression by Bassil, Maya

“…The present results enrich our understanding of how exercise and different diets coordinate to induce BDNF gene expression and may be used in identifying novel therapeutic targets for depression…”
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Gene therapy for spinal muscular atrophy: the Qatari experience by Hossamaldein Gaber Ali (14152632)

“…</p><h2>Other Information</h2><p dir="ltr">Published in: Gene Therapy<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1038/s41434-021-00273-7" target="_blank">http://dx.doi.org/10.1038/s41434-021-00273-7</a></p><p dir="ltr">Additional institutions affiliated with: National Center for Rare Disease in Qatar - HMC</p>…”

Claudins in ovarian cancer: emerging biomarkers and therapeutic targets by Lubna Therachiyil (4246156)

“…Despite these advancements, challenges remain in comprehensively understanding claudin functions and in the development of effective claudin-targeted therapies. This review consolidates existing knowledge regarding claudins in OC, focusing on their expression patterns, biological functions, diagnostic and prognostic significance, and therapeutic implications. …”

Efficient experimental design for uncertainty reduction in gene regulatory networks by Roozbeh Dehghannasiri (5725805)

“…The proposed approximate method also outperforms the random selection policy significantly.</p><p dir="ltr">Erratum - Erratum to: Efficient experimental design for uncertainty reduction in gene regulatory networks: <a href="https://dx.doi.org/10.1186/s12859-015-0839-y" target="_blank">https://dx.doi.org/10.1186/s12859-015-0839-y</a>, published online 14 December 2015.…”

Gene expression data analysis identifies multiple deregulated pathways in patients with asthma by Reem H. Alrashoudi (18629731)

“…The data highlight the multifactorial nature of asthma, but revealed no significant overlap with the gene expression profiles from different datasets interrogated in current studies. …”

Gene-specific machine learning model to predict the pathogenicity of BRCA2 variants by Mohannad N. Khandakji (13885434)

“…</p><p><br></p><h3>Conclusion</h3><p dir="ltr">This new, gene-specific model is an accurate method for interpreting the pathogenicity of variants in the BRCA2 gene. …”

Prevalence of SPOP and IDH Gene Mutations in Prostate Cancer in a Jordanian Population by Mohammed S. Alorjani (22282495)

“…The obtained specimens were subjected to genomic DNA extraction, PCR amplification, and direct sequencing of exons 4, 5, 6, and 7 of the <i>SPOP</i> gene and exon 6 of the <i>IDH1</i> gene. <i>SPOP</i> gene mutations were found in 17% of PCa cases, while no mutation was detected in the screened exon 6 of the<i> IDH1</i> gene. …”

Molecular Profiling Reveals Limited Targetable Biomarkers in Neuroendocrine Carcinoma of the Cervix by Adela Cimic (14908512)

“…Although NTRK protein expression was observed in 21% of the cases, none of these had <em>an NTRK</em> gene fusion. PD-L1 expression (10%) and high tumor mutational burden (3%) were significantly less frequent in NEC compared with the squamous cell carcinoma cohort (79% and 11%, respectively). …”

Deletion of beta‐fructofuranosidase (invertase) genes is associated with sucrose content in Date Palm fruit by Joel A. Malek (10327973)

“…We found significant association of dried date sucrose content and a genomic region that contains 3 tandem copies of the beta-fructofuranosidase (invertase) gene in the reference Khalas genome, a low-sucrose fruit. …”

Correlation of Immunological and Histopathological Features with Gene Expression-Based Classifiers in Colon Cancer Patients by Simone van de Weerd (18282199)

“…Contingency tables were constructed and a χ2 test was used to test for statistical significance. Odds ratios with 95% confidence intervals were calculated. …”

PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer by Caroline Spasojevic (3619418)

“…Together, these results establish PKD1 as a poor prognostic factor and a potential therapeutic target in TNBC.</p><h2>Other Information</h2><p dir="ltr">Published in: Oncotarget<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.18632/oncotarget.25292" target="_blank">https://dx.doi.org/10.18632/oncotarget.25292</a></p>…”

Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications by Jingxuan Shan (4711089)

“…We found a highly significant association between the <b><i>CCND1</i></b><b> </b><b>rs614367-TT</b> genotype (OR = 5.14; <i>P</i> = 0.004) and TNBC risk, and identified a significant association between the <b>rs614367-T</b> allele and decreased PFS in TNBC. …”