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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Discover: across the spectrum of grades
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Distinct genomic features across cytolytic subgroups in skin melanoma
Published 2022“…SBS7a/b, SBS5 and SBS1 were the most prevalent mutational signatures across both cytolytic subgroups, but SBS1 differed significantly between them. …”
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The relationship between trait emotional intelligence and creativity across subject domains
Published 2011“…In contrast, strong relationships were demonstrated between personality traits, including trait EI, and creativity, some of which varied significantly across subject domains. Results suggest that future research will have to pay particular attention to individual differences in the affective parts of the personality realm that are comprehensively captured by the construct of trait EI.…”
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Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss
Published 2018“…Significant decreases in SLC7A8 transport activity was detected for patient’s variants (p.Val302Ile, p.Arg418His, p.Thr402Met and p.Val460Glu) further supporting a causative role for SLC7A8 in ARHL. …”
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Analysing Satellite Imagery Classification under Spatial Domain Shift across Geographic Regions
Published 2025“…In this paper, we address the limitations of existing datasets in capturing distribution shifts caused by geospatial differences between geographic regions by constructing a new, large-scale dataset called Domain Shift across Geographic Regions (DSGR). …”
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Validating a Structural Model of Destination Image, Satisfaction, and Loyalty Across Gender and Age
Published 2015“…After examining the validated structural model across different groups of respondents based on gender, age, and the gender by age interaction, we found that the model constructs differ across some of the groups. …”
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Ranking Investment Opportunities Across Risk-Aversion Levels: Application to Islamic and Conventional Indices
Published 2025“…In bear markets, Islamic indices dominate in most regions, with the exception of Emerging Markets, where dominance is partial, and Japan, where no clear difference is observed. Over the full sample, most markets show no significant long-run AcademicEditor: ThanasisStengos Received: 21September2025 Revised: 22October2025 Accepted: 3November2025 Published: 7 November2025 Citation: Leduc, G., &Perera, S. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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A comparison of the influence of personal and cultural values on the consumption of luxury goods across Arab regions
Published 2016“…Consumption patterns across different cultures are influenced by several factors, including personal and cultural ones. …”
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A Real-Time Energy Management System Across Diverse Energy Sectors in Smart Cities
Published 2024Get full text
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