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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Estimation of Above-Ground Carbon-Stocks for Urban Greeneries in Arid Areas: Case Study for Doha and FIFA World Cup Qatar 2022
Published 2021“…<p>Urban areas are significant sources of anthropogenic carbon dioxide (CO<sub>2</sub>), which elevates air pollution. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Gender differences in personal values
Published 2015“…Purpose – The purpose of this paper is to explore gender differences in personal values in an Arab country. Design/methodology/approach – Based on a sample of 137 participants, the Kruskal-Wallis test was used to identify if the mean scores or ranks of personal values scores were significantly different between males and females. …”
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Solid waste treatment opportunities in the Palestinian authority areas
Published 2008“…Municipal services in the Palestinian Authority (PA) areas, including the West Bank and Gaza Strip (WBGS), are facing serious difficulties that have been intensified following the outbreak of the Palestinian uprising in late September 2000. …”
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Staff Development: A Study Into The Significance of Staff Professional Development Programs for Educators and Students Achievement
Published 2011“…The concept of staff professional development and its effectiveness has been a key area of discussion for long. Several authors/ researchers have made an attempt to touch upon the different dimensions associated with PD programs. …”
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Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss
Published 2018“…Significant decreases in SLC7A8 transport activity was detected for patient’s variants (p.Val302Ile, p.Arg418His, p.Thr402Met and p.Val460Glu) further supporting a causative role for SLC7A8 in ARHL. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Academic Subject Areas and English Language Learning Strategies: Any Relationships?
Published 2018“…The results showed that the preference for learning strategies differed significantly between students of different subject areas. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Enhancing Urban Connectivity and Regeneration of Historic Areas: Case Study of Heart of Sharjah
Published 2020“…A unique and significant historical district in Sharjah called ‘Heart of Sharjah’ is analyzed and assessed in terms of its livability and connectivity through a resilient urban framework. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Characterization and Modeling of Damage in Steel at Different Strain Rates
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Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
Published 2024“…<p>Rapid urbanization primarily converts naturally vegetated areas and pervious surfaces into impervious built-up areas, significantly transforming microclimates and ecological dynamics. …”