Addition of sphingosine-1-phosphate to human oocyte culture medium decreases embryo fragmentation by Zreik, Tony

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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex by Wesam S. Ahmed (10170053)

“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”

L1-CAM knock-down radiosensitizes neuroblastoma IMR-32 cells by simultaneously decreasing MycN, but increasing PTEN protein expression by Rached, Johnny

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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. …”

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... by Vijay Ganji (8710491)

“…In conclusion, serum 25(OH)D ≥75 nmol/L is associated with positive indicators related to cardiometabolic diseases in US adults.…”

Both decreasing interstructural space size and increasing total cover increase shrimp abundance on artificial structures deployed in a UAE seagrass bed by Bartholomew, Aaron

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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”

Consanguinity-associated kidney diseases in Lebanon by Barbari, A

“…Consanguinity-associated kidney diseases pattern seems to differ from that of the general HD population by disease diagnosis and initiation at a younger age and a significantly higher risk for familial renal disease. …”
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Association of coronary artery disease and chronic kidney disease in Lebanese population by Milane, Aline

“…Background: More evidence is emerging on the strong association between chronic kidney disease (CKD) and cardiovascular disease. …”
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Disease-Associated α-Synuclein Aggregates as Biomarkers of Parkinson Disease Clinical Stage by Nour Majbour (3528548)

“…<h3>Background and Objectives</h3><p dir="ltr">Robust biomarkers that can mirror Parkinson disease (PD) are of great significance. In this study, we present a novel approach to investigate disease-associated α-synuclein (αSyn) aggregates as biomarkers of PD clinical stage.…”

Association between dental diseases and history of stroke in the United States by Hatem A. Alhadainy (14153157)

“…</p> <h2>Results</h2> <p>Number of missing teeth was found to be significantly associated with the self-reported history of stroke. …”

Association of hypertension with coronary artery disease onset in the Lebanese population by Milane, Aline

“…Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001). …”
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Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone by Ilhame Diboun (3522413)

“…Additionally, methylation profiles in 11 regions showed Bonferroni-significant association with disease severity including six islands (located in VCL, TBX5, CASZ1, ULBP2, NUDT15 and SQSTM1), two gene bodies (CXCR6 and DENND1A), and 3 promoter regions (RPL27, LINC00301 and VPS29). …”

Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies by Fawaz E., Alanazi

“…Here, metformin significantly decreased VISTA and AHR levels in vitro and in vivo. …”
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Current trends and future orientation in diagnosing lung pathologies: A systematic survey by Noorizadeh, Mohammad

“…Lung diseases pose a significant threat to public health worldwide, resulting in a substantial number of fatalities. …”
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Prevalence of non-communicable disease and the associated factors among healthcare workers in Qatar by Ayman Al-Dahshan (8962568)

“…<h3>Background</h3><p dir="ltr">Non-communicable diseases (NCDs) significantly impact global health and contribute to economic burdens and premature deaths, with healthcare workers (HCWs) being at high risk. …”

PGAP3 Associated with Hyperphosphatasia with Mental Retardation Plays a Novel Role in Brain Morphogenesis and Neuronal Wiring at Early Development by Sahar I. Da’as (9631717)

“…<p dir="ltr">Recessive mutations in Post-GPI attachment to proteins 3 (PGAP3) cause the rare neurological disorder hyperphosphatasia with mental retardation syndrome 4 type (HPMRS4). Here, we report a novel homozygous nonsense mutation in PGAP3 (c.265C>T-p.Gln89*), in a 3-year-old boy with unique novel clinical features. …”

Large-scale association analysis identifies new risk loci for coronary artery disease by Deloukas, Panos

“…Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r2 < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). …”
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Large scale association analysis identifies three susceptibility loci for coronary artery disease by El-Khazen, Georges

“…Replication of the most significantly associated polymorphisms in multiple populations with distinctive genetic backgrounds and lifestyles is crucial to the understanding of the pathophysiology of a multifactorial disease like CAD. …”
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Whole blood DNA aberrant methylation in pancreatic adenocarcinoma shows association with the course of the disease by El Maarri, Osman

“…This was found to be significantly associated with higher risk for pancreatic ductal adenocarcinoma. …”
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