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Factors Influencing the Magnitude and Clinical Significance of Drug Interactions Between Azole Antifungals and Select Immunosuppressants
Published 2006“…The magnitude of drug interactions between azole antifungals and immunosuppressants is drug and patient specific and depends on the potency of the azole inhibitor involved, the resulting plasma concentrations of each drug, the drug formulation, and interpatient variability. Many factors contribute to variability in the magnitude and clinical significance of drug interactions between an immunosuppressant such as cyclosporine, tacrolimus, or sirolimus and an antifungal agent such as ketoconazole, fluconazole, itraconazole, voriconazole, or posaconazole. …”
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Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity
Published 2013“…<p dir="ltr">Sedentary lifestyle and excessive energy intake are prominent contributors to obesity; a major risk factors for the development of insulin resistance, type 2 diabetes and cardiovascular diseases. …”
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A clustering metaheuristic for large orienteering problems
Published 2022“…The metaheuristic aims to dramatically improve the computation time of a given Orienteering Problem algorithm without a significant decrease in the solution quality of that algorithm, especially for large Orienteering Problems. …”
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<i>CCN3</i>,<i> POSTN</i>, and <i>PTHLH</i> as potential key regulators of genomic integrity and cellular survival in iPSCs
Published 2024“…<p dir="ltr">Reprogramming human somatic cells into a pluripotent state, achieved through the activation of well-defined transcriptional factors known as OSKM factors, offers significant potential for regenerative medicine. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
Published 2021“…The results of the conducted computational experiments indicate that an increase in infrastructure investment through high speed chargers can significantly decrease the size of the necessary fleets. …”
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Power factor correction capacitors; essentials and cautions
Published 2000“…In electrical installations with a low power factor, significant cost savings can be made through the application of power factor correction. …”
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Parallel multi-voltage power minimization in VLSI circuits. (c2013)
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Exploring the Transformative Potential of Generative AI in Mechanical Engineering Education
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EXPLORING THE FACTORS THAT AFFECT THE EFFICIENT UTILIZATION OF IT IN CONSULTING OFFICES
Published 2020“…The development of information technology (IT) offers the potential for significant improvements in the efficiency of communication and data exchange in the production process, if effectively employed. …”
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The predictors of perforated appendicitis in the pediatric emergency department: A retrospective observational cohort study
Published 2021“…Objective Appendiceal perforation has significant effects on perioperative morbidity and postoperative outcome. …”
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Adoption of blockchain technology in healthcare systems: benefits, potential applications, and challenges
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Women Entrepreneurship for Sustainability: Investigations on Status, Challenges, Drivers, and Potentials in Qatar
Published 2022“…However, despite the conspicuous support the state has been providing them with in an aim to promote for their active economic participation as part of Qatar National Vision 2030, women’s full potential to contribute both socially and economically is either hindered or not fully acknowledged due to several socio-economic factors. …”
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Numerical investigation of the potential of using hydrogen as an alternative fuel in an industrial burner
Published 2024“…Statistical analysis identified <i>Φ</i>, hydrogen content (H<sub>2</sub>%), and flame stability as key factors, with 50%–75% hydrogen blends minimizing emissions and optimizing performance, emphasizing hydrogen’s potential with controlled MFR and air adjustments.…”
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Adoption of Blockchain Technology: Exploring the Factors Affecting Organizational Decision
Published 2022“…There is a knowledge gap in what specific factors, among the plethora of factors reported in the extant literature, affect the organizational adoption of BCT in Australia. …”
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Invasive Species as Rivals: Invasive Potential and Distribution Pattern of Xanthium strumarium L.
Published 2022“…<p dir="ltr">Xanthium strumarium L. is a globally successful invasive herb that has had significant negative ecological, economic and social impacts in many world regions. …”