Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer by Rasha M. Sareyeldin (18131371)

“…Despite the anti-HER2 and cytotoxic chemotherapy, HER2 subtype is an aggressive disease with significant mortality. Recent advances in molecular biology techniques, including gene expression profiling, proteomics, and microRNA analysis, have been extensively used to explore the underlying mechanisms behind human breast carcinogenesis and metastasis including HER2-positive breast cancer, paving the way for developing new targeted therapies. …”

Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity by Mohamed Abu-Farha (18535590)

“…In functional assays, our data indicated that ectopic expression of HDAC4 significantly impaired TNF-α-dependent activation of NF-κB, establishing thus a link between HDAC4 and regulation of the immune system. …”

Downregulation of Lymphoid enhancer‐binding factor 1 (<i>LEF‐1)</i> expression (by immunohistochemistry and/ flow cytometry) in chronic Lymphocytic Leukemia with atypical immunophe... by Dina S. Soliman (14779333)

“…The ratio for <i>LEF-1</i> expression in malignant B-cells/NK (by flow cytometry) in CLL/SLL with classic immunophenotype was higher than atypical CLL and is significantly higher in other small B-cell lymphomas (<i>P </i>< .01). …”

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes by Noura Aldous (15429873)

“…Several important transcription factors (TFs) required for pancreatic islet development and function were significantly downregulated in FOXA2–/–PPs such as PDX1, NKX6.1, SOX9, PAX4, GATA6, NEUROG3, NEUROD1, and PTF1A, which were also validated by RT-qPCR. …”

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes by Noura Aldous (15429873)

“…To identify differentially expressed miRNAs (DEmiRs), and genes (DEGs), two differentFOXA2^–/^–iPSC lines were differentiated into PPs.FOXA2^–/^–PPs showed a significant reduction in the expression of the main PP transcription factors (TFs) in comparison to WT-PPs. …”

The combinatory effects of diet and exercise on BDNF gene expression by Bassil, Maya

“…Brain Derived Neurotrophic Factor (BDNF) plays a critical role in the synaptic activity and plasticity of mature neurons and regulates the formation and maintenance of memory. …”
Get full text
Get full text
Get full text

Analysis of facial emotion expression in eating occasions using deep learning by Elif Yildirim (17725965)

“…We measured the neural, behavioral, and physical manifestations of emotions with a mobile app and recognize emotional experiences from facial expressions. In this research, we used three different situations to test whether there could be any factor other than the food that could affect a person’s mood. …”

Differing endometrial expression of calcium modulating transient receptor potential channels by Maryam Ghavideldarestani (11862563)

“…</p><p dir="ltr">Endometrial samples at day 21 of the menstrual cycle (MC) from 15 patients (Table 1) prior to ART were taken; five women with normal female investigation, but with male factor infertility (MFI), acted as controls; five women had unexplained infertility (UI) and five had PCOS with no MFI. …”

The unified effect of data encoding, ansatz expressibility and entanglement on the trainability of HQNNs by Muhammad Kashif (3923483)

“…Our framework aims to empirically analyze the joint impact of these factors on the training landscape of HQNNs. Our results show that the occurrence of the BP problem in HQNNs is contingent upon the expressibility of the underlying ansatz and the type of the adopted data encoding technique. …”

Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion by Khoury, Nathalie

“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
Get full text
Get full text
Get full text

Gene expression data analysis identifies multiple deregulated pathways in patients with asthma by Reem H. Alrashoudi (18629731)

“…The data highlight the multifactorial nature of asthma, but revealed no significant overlap with the gene expression profiles from different datasets interrogated in current studies. …”

Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells by Castellino, R.C.

“…Daoy and D556 human medulloblastoma cells pre-treated for 1 h with 0.2 μM sunitinib demonstrated induction of PTEN expression and significant inhibition of PDGFR signaling activity and transactivation of EGFR, in a RAS-independent manner, in response to PDGF-BB stimulation. …”
Get full text
Get full text
Get full text
Get full text

The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas by Abou-Ghazal, Mohamed

“…We sought to determine the incidence of phosphorylated STAT3 (p-STAT3) expression in malignant gliomas of different pathologic types, whether p-STAT3 expression is a negative prognostic factor, and whether p-STAT3 expression influences the inflammatory response within gliomas. …”
Get full text
Get full text
Get full text
Get full text

A positive change in energy balance modulates TrkB expression in the hypothalamus and nodose ganglia of rats by Zeeni, Nadine

“…Brain-derived neurotrophic factor (BDNF) and its TrkB receptor play critical roles in the synaptic activity and plasticity of mature neurons and enhance adult neurogenesis. …”
Get full text
Get full text
Get full text

A jojoba (Simmondsia chinensis) seed cake extracts express hepatoprotective activity against paracetamol-induced toxicity in rats by Firas Feki (17545638)

“…The PC intoxication altered the serum biomarkers, the oxidative status, and the Tumor necrosis factor alpha (TNF-α), Bax and Bcl-2 protein expressions of tested animals. …”

Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response by Noura Al-Zeheimi (5177066)

“…From a panel of tested proteins and genes, we found that the levels of plasma NRP-1, placenta growth factor (PlGF) and immune cell expression of the transcription factor <i>SNAI1</i> before and after NAC were significantly different. …”

When digital spaces matter: The influence of uniqueness and place attachment on self-identity expression with brands using generative AI on the metaverse by Farah, Maya F.

“…The goal was to understand how the need for uniqueness influences self-identity expression and to examine how these factors are affected by attachment to virtual places. …”
Get full text
Get full text
Get full text
Get full text

Local Over-Expression of VEGF-DDNDC in the Uterine Arteries of Pregnant Sheep Results in Long-Term Changes in Uterine Artery Contractility and Angiogenesis by Abi Nader, Khalil

“…Reduced uterine artery blood flow (UABF) is a common cause of fetal growth restriction; abnormalities in angiogenic factors are implicated. Previously we showed that adenovirus (Ad)-mediated VEGF-A165 expression in the pregnant sheep uterine artery (UtA) increased nitric oxide synthase (NOS) expression, altered vascular reactivity and increased UABF. …”
Get full text
Get full text
Get full text
Get full text

Nurturing Sustainability: Infuential Factors in Shaping Gen Z Behavior and Satisfaction in the UAE by Baber, Hasnan

“…Key predictors, including environmental concern (β = 0.257), social media engagement (β = 0.246), and willingness to pay (β = 0.212), show significant positive effects. While sustainable behavior strongly enhances satisfaction (β = 0.598), posting sustainability content on social media does not (β = −0.090), suggesting a distinction between online expression and internal fulfillment. …”
Get full text

Exploring the Impact of Social, Cultural, and Science Factors on Students’ STEM Career Preferences by Nasser Mansour (17541822)

“…Social factors were identified as significant mediators, amplifying the influence of gender on career decisions and shaping gender-related job preferences. …”