Genetic evaluation of cardiomyopathies in Qatar identifies enrichment of pathogenic sarcomere gene variants and possible founder disease mutations in the Arabs by Kholoud N. Al‐Shafai (18459009)

The identification of highly upregulated genes in claudin-low breast cancer through an integrative bioinformatics approach by Hatem, Zayed

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The identification of highly upregulated genes in claudin-low breast cancer through an integrative bioinformatics approach by Hatem Zayed (835448)

Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping by Karsten Suhre (67967)

The combinatory effects of diet and exercise on BDNF gene expression by Bassil, Maya

“…Future work will investigate whether the effect found is restricted to leucine or may be extended to other branched chain amino acids such as isoleucine or valine. The present results enrich our understanding of how exercise and different diets coordinate to induce BDNF gene expression and may be used in identifying novel therapeutic targets for depression…”
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Parkinson’s disease and schizophrenia interactomes contain temporally distinct gene clusters underlying comorbid mechanisms and unique disease processes by Kalyani B. Karunakaran (12478431)

“…PD and SZ interactomes formed four gene clusters with distinct temporal identities (Disease Gene Networks or ‘DGNs’1-4). …”

Accelerated epigenetic aging and DNA methylation alterations in Berardinelli–Seip congenital lipodystrophy by Abeer Qannan (14779192)

“…We could also observe significant hypomethylation in the promoter of the dual specificity phosphatase 22 gene when comparing CGL2 patients versus controls. …”

System biology approaches identified novel biomarkers and their signaling pathways involved in renal cell carcinoma with different human diseases by Md. Saddam Hossen (18278698)

Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer by Rasha M. Sareyeldin (18131371)

“…Despite the anti-HER2 and cytotoxic chemotherapy, HER2 subtype is an aggressive disease with significant mortality. Recent advances in molecular biology techniques, including gene expression profiling, proteomics, and microRNA analysis, have been extensively used to explore the underlying mechanisms behind human breast carcinogenesis and metastasis including HER2-positive breast cancer, paving the way for developing new targeted therapies. …”

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 by Olfa Khalifa (10914452)

“…</p> <p>Results: Treatment with 200nM Ex-4 for 3h decreased the OA-induced lipid buildup significantly (p<0.05). Concurrently, Ex-4 significantly lowered the expression levels of De novo lipogenesis genes such as SREBP-1, SCD-1and ACC. …”

DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer by Varun Sasidharan Nair (5396393)

“…To study the role of DNA methylation, we checked the promoter CpG methylation of ICs and ligands and found that only CTLA-4 and TIGIT, among other genes, were significantly hypomethylated in TT compared with NT. …”

Systems biology analysis reveals NFAT5 as a novel biomarker and master regulator of inflammatory breast cancer by Andrea Remo (447375)

“…Pathway enrichment analysis was used to characterize predicted targets of candidate genes. …”

MicroRNA profiling in intraocular medulloepitheliomas by Edward, Deepak P.

“…The web-based DNA Intelligent Analysis (DIANA)-miRPath v2.0 was used to perform enrichment analysis of differentially expressed (DE) miRNA gene targets in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway. …”
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Optimisation of PV Cleaning Practices: Comparison Between Performance Based and Periodic Based Approaches by ALHAJERI, RASHED ABDULLA

“…Solar energy has the largest untapped reserve in energy and is one of the fastest emerging energy markets. …”
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Unveiling the dynamics of the breast milk microbiome: impact of lactation stage and gestational age by Parul Singh (191877)

“…Specifically, mature BM samples were significantly enriched in Veillonella and lactobacillus (Kruskal Wallis; p < 0.001) compared to colostrum. …”

Effect of consanguinity on birth weight for gestational age in a developing country by Wakim, Gerard

“…No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. …”
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DNA methylation signatures in Blood DNA of Hutchinson–Gilford Progeria syndrome by Yosra Bejaoui (8552574)

“…Comparing aberrantly methylated sites in progeroid laminopathies, classic Werner syndrome, and Down syndrome revealed a common significantly hypermethylated region in close vicinity to the transcription start site of a long non-coding RNA located anti-sense to the Catenin Beta Interacting Protein 1 gene (<i>CTNNBIP1</i>). …”

β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo by Daaboul, Hamid E.

“…Also, there was a significant decrease in p-Erk and p-Akt protein levels. …”
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Distinct genomic features across cytolytic subgroups in skin melanoma by Constantinos Roufas (4871131)

“…We assessed enrichment for immune-related gene sets within CYT-high tumors, whereas, CYT-low tumors were enriched for non-immune related gene sets. …”

Renewable Energy, Coal as a Baseload Power Source, and Greenhouse Gas Emissions: Evidence from U.S. State-Level Data by Squalli, Jay

“…After controlling for other sources of emissions, U.S. states that produce a larger share of renewable energy are found to have lower GHG emissions. …”
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