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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Grid Iron Patterns & Detached Villas as the Main Drivers of Sharjah City’s Urban Sprawl
Published 2021“…On the other hand, the same study proved that the grid system and the villa model are the main reason behind the urban sprawl of the city. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Type II diabetes mellitus and hyperhomocysteinemia
Published 2017“…Background Elevated homocysteine (Hc) levels have a well-established and clear causal relationship to epithelial damage leading to coronary artery disease. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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COVID-19 and neuropathy in type 2 diabetes
Published 2025“…The long-COVID group exhibited significant changes in triglycerides and LDL (<i>P</i> < 0.05 for both) and body weight (<i>P</i> < 0.01) at follow-up. …”
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Advanced Techniques for Predicting the Future Progression of Type 2 Diabetes
Published 2020“…Although machine learning techniques have been applied for disease diagnosis, there is little work done on long term prediction of disease, type 2 diabetes in particular. Moreover, finding discriminative features or risk-factors responsible for the future development of diabetes plays a significant role. …”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
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Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus
Published 2017“…Despite adequate glycemic and blood pressure control, treated type 2 diabetic hypertensive subjects have a significantly elevated overall/cardiovascular risk. …”
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Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction
Published 2017“…<h3>Background</h3><p dir="ltr">Elevated homocysteine (Hc) levels have a well-established and clear causal relationship to epithelial damage leading to coronary artery disease. …”
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Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes
Published 2021“…<h3>Background and Purpose</h3><p dir="ltr">Patients with type 2 diabetes (T2D) have increased risk of cardiovascular disease (CVD), encompassing myocardial infarction, stroke, and peripheral vascular disease. …”
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Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance
Published 2025“…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…”
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Bifidobacterium reduction is associated with high blood pressure in children with type 1 diabetes mellitus
Published 2021“…<p dir="ltr">Children with Type 1 diabetes mellitus (T1DM) have an elevated risk of abnormal blood pressure (BP) measurements and patterns. …”
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