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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Enforceability of DAB's Decision in the Context of the Construction Contract: A Comparison between English & UAE Law
Published 2023“…This dissertation's main objective is to examine the legal framework governing the enforcement of DAB decisions under English and UAE law. Employing a doctrinal approach, the study aims to identify similarities and differences in the enforceability of DAB decisions in both jurisdictions and highlight the challenges associated with enforcing DAB decisions under UAE law. …”
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Influence of Cognitive Bias on Decision Making in Mega Projects
Published 2020“…Additionally, the influence of demographic attributes on cost overrun was also checked. 101 responses were received and analyzed through variance analysis, correlation, association analysis, and hierarchical regression. The association analysis which generated the key findings of the study indicated that work experience, controllability, dread, and cost decision making have significant influence on cost overrun due to over optimism while other factors were not significant. …”
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Making the Sourcing Decision of Software Maintenance and Information Technology
Published 2021“…Outsourcing of IT and software maintenance seem very promising, but a number of factors, risks, and challenges associated with the outsourcing process that make the sourcing decision very complicated. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Analyzing Drivers’ Passing Decision on Two-Lane Two-Way Highways
Published 2022“…Passing maneuvers on rural two-lane highways have significant implications on safety, highway performance, and traffic operations. …”
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Empirical Investigation of Influencing Factors Regarding Offshore Outsourcing Decision of Application Maintenance
Published 2021“…Maintenance of software is not only time consuming but also requires a significant human resources' ratio. Mostly, software acquisition and maintenance consume a big portion of the total IT budget. …”
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The Impact of AI on Decision-Making in Educational Management: Benefits, Risks, and Ethical Concerns
Published 2024“…This dissertation explores the impact of AI on decision-making in educational management, focusing on the benefits, risks, and ethical concerns associated with its use. …”
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Application of Data Mining to Predict and Diagnose Diabetic Retinopathy
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doctoralThesis -
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Epidemiology of prehospital emergency calls according to patient transport decision in a middle eastern emergency care environment: Retrospective cohort‐based
Published 2024“…Bivariate analysis revealed significant associations across several variables, though multicollinearity was identified as a challenge. …”
