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decrease » increase (Expand Search)
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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A Novel Steganography Technique for Digital Images Using the Least Significant Bit Substitution Method
Published 2022“…Therefore, the proposed work, in this paper, is based on the Least Significant Bit (LSB) substitution method. The LSB substitution method can minimize the error rate in embedding process and can achieve greater reliability in criteria, using novel algorithm based on value difference. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Here, we dissect the mechanism underlying the increased binding affinity of the N501Y mutant for ACE2 using molecular dynamics (MD) simulations of the available ACE2-S1-RBD complex structure (6M0J) and show a prolonged and stable interfacial interaction of the N501Y mutant S1-RBD with ACE2 compared to the wild type S1-RBD. …”
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Optimizing register binding in FPGAs using simulated annealing
Published 2017“…This solution optimizes the assignment of variables onto registers when standard techniques such as clique partitioning are used; and onto on-chip memory banks when two different memory binding techniques are used. …”
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Knowledge-based virtual outdoor weather event simulator using unity 3D
Published 2022“…In this context, knowledge representation and processing have recently shown a significant contribution to the simulation modeling domain, where knowledge graphs have been used in different fields to build knowledge representations for multiple purposes. …”
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Pore-scale simulation of fine particles migration in porous media using coupled CFD-DEM
Published 2022“…The time required to develop bridging and subsequent clogging of the pore space that lead to permeability reduction decreases as the flow velocity increases. The size of the fine particles has a significant impact on permeability reduction where the reduction in permeability increases as the size of particles increases. …”
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Simulating the thermal behavior of buildings using artificial neural networks-based coarse-grain modeling
Published 2004“…The main advantages of the approach compared to conventional simulation methods are (1) simplified model construction for the end-user; (2) simplified model reconfiguration; (3) significantly faster simulation runs (orders of magnitude faster for two- and three-dimensional models); and (4) potentially more accurate results. …”
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Data of simulation model for photovoltaic system's maximum power point tracking using sequential Monte Carlo algorithm
Published 2024“…The provided data facilitate precise replication of the output, saving significant simulation time. Additionally, these data can be readily applied to compare algorithmic results referenced by (Babu, T.S. et al., 2015; PrasanthRam, J. et al., 2017) [2,3], and contribute to the development of new processes for practical applications.…”
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Modelling the Impact of Bottlenecks on Arterial Travel Time Using Neural Networks
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Qualitative and Quantitative Investigation of Multiple Large Eddy Simulation Aspects for Pollutant Dispersion in Street Canyons Using OpenFOAM
Published 2019“…Numerous studies reviewed the state-of-the-art models, proposed best-practice guidelines and explored, using various software, how different approaches (e.g., Reynolds-averaged Navier–Stokes (RANS), large eddy simulations (LES)) inter-compare. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”