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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Seasonal and spatial variations in concentration, diversity, and antibiotic resistance of ambient bioaerosols in an arid region
Published 2024“…<p dir="ltr">The airborne <u>microbiome</u> significantly influences human health and <u>atmospheric processes</u> within Earth's troposphere and is a crucial focus for scientific research. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Holocene relative sea-level variations and archeological implications, Abu Dhabi western region, United Arab Emirates
Published 2020“…Data obtained from our surveys highlight significant differences and suggest local processes that need to be understood. …”
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Discovery of new genomic regions and candidate genes implicated in the natural variation of barley peduncle length and plant height
Published 2024“…The peduncle’s developmental properties under dry (drought and heat) conditions make it an ideal attribute for studying its function in tolerance and adaption processes. Thus, we intend to investigate the natural phenotypic and genetic variation of the peduncle length, as well as the genetic reasons underpinning its growth in dry (drought and heat) environments. …”
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An evaluation of recruitment and selection processes in three organizations in the UAE
Published 2011“…This case study research reveals strong variation in recruitment and selection policies and practices in the small sample of three UAE organizations and also shows some significant areas of divergence from best practice models. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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An image processing and genetic algorithm-based approach for the detection of melanoma in patients
Published 2018“…The first phase consists of an image processing-based method that extracts the Asymmetry, Border Irregularity, Color Variation and Diameter of a given mole. …”
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Contribution of Soft Skills Set of Project Managers on the Benefits Realization Management Process in the Construction Industry in UAE
Published 2019“…This research aims to explore the significant soft skills set of project managers and check the influence of soft skills on benefit realization management process. …”
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Novel Ternary Adder and Multiplier Designs Without Using Decoders or Encoders
Published 2021“…Extensive simulations (over 160) of the proposed designs in terms of PVT (Process, Voltage, Temperature) variations, noise effect, and scalability studies, along with several benchmark designs using HSPICE simulator, prove the significance of the proposed circuits to decrease the power-delay product (PDP), improve the robustness to process variations, and the noise tolerance. …”
