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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Quality Issues In Online Distance Learning
Published 2020“…The objective of this research is to determine the quality issues of online distance learning and explore the factors which affect the quality of online education. …”
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Detection of statistically significant network changes in complex biological networks
Published 2017“…</p><h3>Methods</h3><p dir="ltr">In this paper, we propose an improvement over the state-of-the-art based on the Generalized Hamming Distance adopted for evaluating the topological difference between two networks and estimating its statistical significance. …”
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Trade Flow and Nation Brand Distance: A Structural Gravity Model Approach
Published 2021“…The results on the impact of NBD on FTA and trade flows provides some interesting insights as the there is a negative and significant moderation impact of NBD on the relationship between FTA and both export and import volume which suggest that a decrease of NBD will increase the effect of FTA on trade flow. …”
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Can Ease of Doing Business Shorten the Distance and Attract Foreign Direct Investment
Published 2021“…Regarding the distance variables, with the exception of geographic distance (GeoDist), all are significant and exhibit their expected signs. …”
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Addressing Challenges of Distance Learning in the Pandemic with Edge Intelligence Enabled Multicast and Caching Solution
Published 2022“…While exploring the opportunities of EI-enabled distance learning, we demonstrate a significant reduction in network operator resource utilization and an increase in user QoE for VNF based multicast transmission.…”
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Deep visual social distancing monitoring to combat COVID-19: A comprehensive survey
Published 2022“…Then, VSDM techniques are carefully reviewed after dividing them into two main categories: hand-crafted feature-based and deep-learning-based methods. A significant focus is paid to convolutional neural networks (CNN)-based methodologies as most of the frameworks have used either one-stage, two-stage, or multi-stage CNN models. …”
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MDPF: Minimum Distance Packet Forwarding for Search Applications in Mobile Ad Hoc Networks
Published 2009“…The algorithm, which is called Minimum Distance Packet Forwarding (MDPF), uses routing information to select the node with the minimum distance. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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An Effective Fault Diagnosis Technique for Wind Energy Conversion Systems Based on an Improved Particle Swarm Optimization
Published 2022“…First, an efficient feature selection algorithm based on particle swarm optimization (PSO) is proposed. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
