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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Knee Angle Affects Posterior Chain Muscle Activation During an Isometric Test Used in Soccer Players
Published 2019“…Results: Within-session reliability showed large variation dependent upon the test position and muscle measured (CV% = 8.8–36.1) Absolute mean EMG activity and percentage of maximum voluntary isometric contraction (MVIC) indicated different magnitudes of activation between the two test positions; however, significant mean differences were present for the biceps femoris only with greater activation recorded at the 30° knee angle (% MVIC: 31 ± 9 vs. 22 ± 7; p = 0.002). …”
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A green route to the synthesis of highly porous activated carbon from walnut shells for mercury removal
Published 2024“…Activated carbon with a high surface area was synthesized using walnut shells with the objective of removing mercury ions. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Kefir, a fermented milk product, exhibits anti‑tumoral activity in vivo; yet its mechanism of action remains elusive. …”
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Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
Published 2020“…<p dir="ltr">In somatic cells/tissues, methylation of ribosomal DNA (rDNA) increases with age and age‐related pathologies, which has a direct impact on the regulation of nucleolar activity and cellular metabolism. …”
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Activation of Src kinase in primary colorectal carcinoma An indicator of poor clinical prognosis
Published 2002“…Increased Src activity significantly correlated with Dukes stage, pT and pN classification, and increased u-PAR levels (P < 0.001). …”
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Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice
Published 2010“…In addition, a significant interaction was found between CCK administration and the HF diet, shown by an increased activation in the PVN, which suggests a decrease the inhibiting action of CCK. …”
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Design, Implementation, and Performance Analysis of Actively
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
Published 2006Get full text
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Removal of Methylene Blue from Water Using Magnetic GTL-Derived Biosolids: Study of Adsorption Isotherms and Kinetic Models
Published 2023“…<p dir="ltr">Global waste production is significantly rising with the increase in population. …”
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Discourse and Multicultural Social Activity in Postwar Lebanon
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Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines
Published 2018“…Complex 1 demonstrated only marginal activity in the dark; its cytotoxicity increased significantly upon photoactivation with a high phototoxicity index (PI = [IC50 dark]/[IC50 light]) ranging from 39.2‐fold in A549 to over 100‐fold in MDA‐MB‐231. …”
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Lower limb EMG activation during reduced gravity running on an incline. Speed matters more than hills irrespective of indicated bodyweight
Published 2021“…Increasing running speed was associated with the largest change in activity, with smaller effects for increasing bodyweight and inclination. …”
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Phospholipase C negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells
Published 2007“…The inhibition of phospholipase C (PLC)c causes a twofold increase in Rac and Cdc42 activation that coincides with a dramatic production of atypical filopodialike structures. …”
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