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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patien...
Published 2023“…We demonstrated for the first time that exosomal immuno-oncological proteins/cytokines are potential biomarkers to monitor response to ICIs therapy and can predict the clinical outcomes in NSCLC patients.…”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
Published 2006Get full text
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Light-Responsive Metal-Organic Frameworks (MOFs) For Doxorubicin Controlled Release
Published 2023Get full text
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Identification and Assessment of Risks and Response Strategies in High-Rise Construction Projects
Published 2023Get full text
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T‐cell responses and therapies against SARS‐CoV‐2 infection
Published 2023“…This review focuses on the multifaceted roles of T cells in COVID-19 pathogenesis and rationalizes their significance in eliciting appropriate antiviral immune responses in COVID-19 patients and unexposed individuals. …”
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A Social Constructionist Perspective on the Diffusion of Innovative Fiscal Responsibility Legislation
Published 2013“…This paper augments this approach with a myth perspective that is applied to an analysis of the diffusion of the qualitative fiscal norms embedded in New Zealand's innovative Fiscal Responsibility Act of 1994. The 'prime mover', 'innovative discontinuity' and 'unmodified legislative success' components of the agent significance myth surrounding this fiscal responsibility law (FRL) are examined and the scope and limits of its subsequent diffusion are relat-ed to mutual identification and interaction across pre-established network linkages between actors who have learnt its usefulness. …”
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Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance
Published 2025“…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…”
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Alleviation of drought and salt stress in vegetables: crop responses and mitigation strategies
Published 2022“…Therefore, this review enlightens the updated knowledge of responses (physiological and molecular) against drought and salinity in vegetables and potentially effective strategies to enhance production. …”
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Evaluating the authenticity of ChatGPT responses: a study on text-matching capabilities
Published 2023“…The repeatability and reproducibility of both models were analyzed, showing that the generation of responses remains consistent. However, a two-sample t-test revealed insufficient evidence to support a statistically significant difference between the text-matching percentages of both models. …”
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Short-term behavioural responses to thermal stress by hawksbill turtles in the Arabian region
Published 2014“…Our results indicate that Gulf hawksbills employ thermoregulatory responses which take them out of high temperature and potentially physiology-threatening conditions. …”
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Cold responses and hormonal echoes: a comprehensive view of Raynaud’s vascular dysfunction
Published 2025“…<p dir="ltr">Raynaud’s phenomenon is a peripheral vascular disorder characterized by exaggerated vasoconstrictive response to certain stimuli, most typically cold exposure and emotional stress. …”
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Beauvericin potentiates the activity of pesticides by neutralizing the ATP-binding cassette transporters in arthropods
Published 2022“…The ATP binding cassette transporters (ABC transporters) are considered as the main participants to the pesticide efflux and their neutralization will greatly contribute to potentiate failed treatments. Real-Time PCR analysis of 19 ABC transporter genes belonging to the ABCB, ABCC, ABCG, and ABCH revealed that a broad range of efflux pumps is activated in response to the exposure to pesticides. …”
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Computational identification of genetic subnetwork modules associated with maize defense response to Fusarium verticillioides
Published 2015“…Based on our analysis pipeline, we identified four potential maize defense subnetwork modules. Two were directly associated with maize defense response and were associated with significant GO terms such as GO:0009817 (defense response to fungus) and GO:0009620 (response to fungus). …”
