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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Validity and gender issues in the use of the DISCOVER. Assessment for the identification of gifted minorities
Published 1998“…Rogers, 1994) to assess its construct validity. Other purposes included assessing percentages of identified students and gender differences through the use of the assessment. …”
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
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Educational Test Scores: Interpretation and Use through an Argument-Based Framework
Published 2025“…However, the key question remains: "To what extent are the test scores valid for the purposes they are used?" The interpretation and use of test scores can significantly privilege some test-takers and disadvantage others if the tests are not valid, that is, not meant for or are not appropriate for the purpose they are used. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Validation of the Arabic version of the Social Communication Questionnaire
Published 2019“…<p dir="ltr">Validated screening and diagnostic tools for autism spectrum disorder for use in Arabic-speaking individuals are scarce. …”
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Security Supply Chain Using UAVs: Validation and Development of a UAV-Based Model for Qatar’s Mega Sporting Events
Published 2023“…The key findings of the study are: (1) a valid and reliable UAV-based cybersecurity framework for FIFA mega sporting events was developed; (2) five critical factors were identified, including traceability, security and privacy, trust, acceptability, and preparedness; (3) all factors were significantly and positively correlated, highlighting the complexity of managing security systems in mega sporting events.…”
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Mitigating undercooling and overheating risk in existing desert schools under current and future climate using validated building simulation model
Published 2023“…In Palestine and neighboring regions, buildings are constructed without insulation and mechanical heating and cooling systems, leading to significant thermal discomfort for occupants. To address this issue, the paper in troduces a robust methodology that utilizes a validated building simulation model (BSM) created based on hourly indoor air temperature to assess indoor thermal comfort during winter and summer seasons under both current and future climates. …”
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Hemodynamics of small aneurysm pairs at the internal carotid artery
Published 2012“…The maximum wall shear stress increases for serial aneurysms, but decreases for parallel aneurysms. Interaction between parallel aneurysms is not significant; however, the proximal aneurysm in serial aneurysms may be subject to a greater rupture risk.…”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
Published 2006Get full text
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Effect of corporate ethics and social responsibility on OCB: the role of employee identification and perceived CSR significance
Published 2021“…Partial least square structural equation modeling (PLS-SEM) is used to analyze the data and multi-group analysis is conducted to investigate the role of perceived CSR significance. …”
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Arabic Translation and Validation of the Adult Oral Health Standard Set Questionnaire
Published 2025“…Internal consistency was assessed using Cronbach alpha. Construct validity of the final Arabic version was examined against the validated Arabic Oral Health Assessment WHO questionnaire on 100 participants from different Arab nationalities. …”
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Enhancing Arabic Reading Proficiency as a Second Language: Unveiling the Significance of Audiobooks for Middle School Students
Published 2024“…Considering audiobooks as a useful tool in improving reading skills and language acquisition, this study aims to explore the potential benefits and effectiveness of using audiobooks as a tool for learning for non-Arab students in Dubai, as there is a diverse student population including individuals from various cultural and linguistic backgrounds which can present significant challenges. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”