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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Kefir, a fermented milk product, exhibits anti‑tumoral activity in vivo; yet its mechanism of action remains elusive. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Published 2021“…</p><h3>Conclusions</h3><p dir="ltr">Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. …”
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Performance and durability of anti-soiling and anti-reflective coatings for photovoltaic systems in desert climates
Published 2025“…<p>The efficiency of photovoltaic (PV) systems is significantly hindered by soiling, especially in desert climates where dust accumulation on PV surfaces is prevalent and reduces light transmission and increases maintenance costs. …”
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Hedonic valuation of land protection methods: implications for cluster development.
Published 2014“…The key findings of the study are: (i) proximity to national or state park land and to city or county open space has a significant positive impact on property values, while proximity to national forest land or to privately conserved land exhibits no significant effects; and, (ii) inclusion of a property within a cluster development decreases its value by 17 to 26 %. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…<div><p>Selenium application as sodium selenate was repeatedly shown to have anti-carcinogenic properties by increasing levels of the serine/ threonine protein phosphatase 2A (PP2A) in cancer cells. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) and Ultrasound.
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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Anti-cancer Evaluation of Lebanese Cannabis Oil Extract on Lung and Breast Cancer Cells
Published 2021“…Western blot analysis showed significant increase in MAPK/ERK pathway and the autophagic marker LC3B. …”
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Evaluation of light-activated Ru(II) prodrugs and their photoproducts as potential anti-cancer agents
Published 2020“…Cytotoxicity assays on A375 showed a mean phototoxicity index of 340 at 72 hours, presenting the intracellular aquated photoproducts being effective rather than the dissociating ligands. A significant increase in ROS production and DNA damage was also observed. …”
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Prevalence and clinical significance of antiphospholipid antibodies in patients with coronavirus disease 2019 admitted to intensive care units: a prospective observational study
Published 2022“…<p>Coronavirus disease 2019 (COVID-19) increases the risk of coagulopathy. Although the presence of antiphospholipid antibodies (aPLs) has been proposed as a possible mechanism of COVID-19-induced coagulopathy, its clinical significance remains uncertain. …”
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Intraocular pressure trends following intravitreal injections of anti-VEGF agents for diabetic macular edema
Published 2013“…Purpose: To investigate the intraocular pressure (IOP) trends after intravitreal anti-vascular endothelial growth factor (VEGF) agents for diabetic macular edema (DME). …”
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Andrographolide pre-treatment enhances the anti-tumor activity of topotecan on acute myeloid leukemia cells in vitro
Published 2016“…The pro-apoptotic effect upon combination of topotecan with andrographolide was further observed using annexin V/PI staining; even though andrographolide alone did not alter cell survival, however, when applied to the cells prior to topotecan treatment, the number of apoptotic cells increased from 16% to 57%. Conclusion: Pretreating acute myeloid leukemia cell lines with non-cytotoxic doses of andrographolide promotes the anti-tumor effect of topotecan in vitro.…”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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