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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Influence of Cognitive Bias on Decision Making in Mega Projects
Published 2020“…The main reasons for cost overrun have been clustered into three groups namely technical, optimism bias and strategic misrepresentation. Since mega projects are increasing in size and number, and their poor performance has been consistent despite various proposals suggested based on project management best practices that have mainly focused on the technical element of implementing mega projects, the performance in mega projects has not improved prompting this study to focus on optimism bias and strategic misrepresentation where if optimism is exceeded, it is termed as over optimism and leads to cost overrun due to significant underestimation of costs. …”
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Published 2021“…</p><h3>Conclusions</h3><p dir="ltr">Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. …”
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Hedonic valuation of land protection methods: implications for cluster development.
Published 2014“…The key findings of the study are: (i) proximity to national or state park land and to city or county open space has a significant positive impact on property values, while proximity to national forest land or to privately conserved land exhibits no significant effects; and, (ii) inclusion of a property within a cluster development decreases its value by 17 to 26 %. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Enhancing Project Success in Construction: The Role of Internal Risk Management, Emotional Intelligence, Cognitive Bias, and Organisational Risk Culture
Published 2024“…The construction industry continues to face significant challenges in contemporary society, and the need to improve project outcomes in this sector has become indispensable. …”
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Tranexamic Acid for Traumatic Injury in the Emergency Setting: A Systematic Review and Bias-Adjusted Meta-Analysis of Randomized Controlled Trials
Published 2024“…Study objectiveTraumatic injury causes a significant number of deaths due to bleeding. Tranexamic acid (TXA), an antifibrinolytic agent, can reduce bleeding in traumatic injuries and potentially enhance outcomes. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
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Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance
Published 2025“…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…”
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YOLO-DefXpert: An Advanced Defect Detection on PCB Surfaces Using Improved YOLOv11 Algorithm
Published 2025“…Accurately identifying small defects on PCB surfaces remains a considerable challenge, particularly under complex background conditions, due to the intricate and compact layout of the boards. …”
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Redox Homeostasis and Inflammation Responses to Training in Adolescent Athletes: a Systematic Review and Meta-analysis
Published 2020“…Following more extended training periods, GSH showed moderate increases (ES 1.131; 95% CI 0.350 to 1.913;<i>Z</i>= 2.839,<i>p</i>= 0.005) while TBARS displayed a small decrease (ES 0.568; 95% CI − 0.062 to 1.197;<i>Z</i>= 1.768,<i>p</i>= 0.077). …”
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An Analysis of Thermal Comfort at the School Outdoor Spaces: A Case Study of the American School of Creative Science, Dubai, UAE
Published 2022“…Additionally, the addition of vegetation alone had an impact on the microclimate decreasing it by 5%. Thus, combining the strategies of vegetation, shade, green facades/roofs and small water features resulted in 5% to 25% reduction in PET depending on the corresponding location being analyzed. …”
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Orthodontic camouflage versus orthodontic-orthognathic surgical treatment in borderline class III malocclusion: a systematic review
Published 2022“…Regarding the vertical jaw relation, one study reported a significant decrease in mandibular plane inclination in OC and a significant increase in OOS. …”