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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Artisanal fishing of spiny lobsters with gillnets — A significant anthropic impact on tropical reef ecosystem
Published 2015“…The analysis of target species using nocturnal visual census demonstrated a significantly higher number of P. echinatus at the site where gillnet use was virtually absent within three sampled habitats, fringe, cave and soft bottom. …”
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Exploring Organizational Sustainability: Themes, Functional Areas, and Best Practices
Published 2019“…In addition, there are around 38 functional areas which are of great significance to sustainability managers from an applied perspective and to researchers for constructing sustainability management models.…”
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
Published 2019“…Specifically, symptom queries were first determined to be significantly predictive of subsequent 12-step queries if the probability of querying a medical symptom by those who later sought information about the 12-step program exceeded the probability of that same query being made by a comparison group of all other Bing users in the United States. …”
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Academic Subject Areas and English Language Learning Strategies: Any Relationships?
Published 2018“…The results showed that the preference for learning strategies differed significantly between students of different subject areas. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A national study on nurses’ retention in healthcare facilities in underserved areas in Lebanon
Published 2013“…Such imbalances are often aggravated in underserved areas, especially in developing countries. Despite the centrality of this issue, there is a dearth of studies that examine the retention of nurses in underserved areas in the Middle East Region. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Dynamic Performance Investigation of Solar‐Driven Vapor Absorption Cooling System for Urban Areas
Published 2025“…<p dir="ltr">Solar energy in urban areas due to excessive air conditioning usage in buildings may significantly reduce the consumption of fossil fuels. …”
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The role of protected areas in modulating vegetation response to climatic stressors in hyper-arid ecosystems
Published 2025“…Results show that vegetation sensitivity to climate drivers increased significantly post-protection. For example, in Al Reem, the effect of evaporation on NDVI shifted from a non-significant, 28.1 (p = 0.136) before 2006 to a significant, 18.5 (p = 0.007) after protection, while the number of precipitation events lost its prior significance (β = 3.4, p = 0.016 → p = 0.981). …”
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Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
Published 2024“…<p>Rapid urbanization primarily converts naturally vegetated areas and pervious surfaces into impervious built-up areas, significantly transforming microclimates and ecological dynamics. …”
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