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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Exergo-technological explicit methodology for gas-turbine system optimization of series hybrid electric vehicles
Published 2017“…An intercooled regenerative reheat cycle is prioritized, offering higher efficiency and higher power density than those of other investigated gas-turbine systems. A series hybrid electric vehicle model is developed and powertrain components are sized by considering the vehicle performance criteria. …”
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Problematic internet usage: the impact of objectively Recorded and categorized usage time, emotional intelligence components and subjective happiness about usage
Published 2022“…Multiple linear regression analysis showed that happiness with phone usage (β = −.17), the actual usage of communication (β = .17), social media (β = .19) and gaming apps (β = .13), and trait EI component of self-control (β = −.28) were all significant predictors of PIU. …”
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Airbag-related penetrating injuries: A case series from a level 1 trauma center
Published 2023“…<h3>Background</h3><p>Airbags have significantly reduced the morbidity and mortality associated with trauma following motor vehicle crashes. …”
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
Published 2019“…</p><h3>Objective</h3><p dir="ltr">Identification of the specific symptoms that most motivate individuals to seek treatment information may offer insights for further improving brief interventions. To this end, we used anonymized internet search engine data to investigate which medical conditions and symptoms preceded searches for 12-step meeting locators and general 12-step information.…”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Multidimensional Risk-Based Real Options Valuation for Low-Carbon Cogeneration Pathways
Published 2023“…A combined price risk was initially estimated by transforming the given price factors representing maximum covariance using principal component analysis (PCA). The trend and volatilities in the major principal component scores (the combined price risk indicator) were modelled using the geometric Brownian motion stochastic process, whose parameters were determined and then used to perform time-series simulation and generate multiple realisations of the principal component. …”
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Preparation of Mesoporous/Microporous MnCo<sub>2</sub>O<sub>4</sub> and Nanocubic MnCr<sub>2</sub>O<sub>4</sub> Using a Single Step Solution Combustion Synthesis for Bifunction Oxy...
Published 2020“…Chronoamperometric (CA) runs for 24 h shows excellent stability of MnCo<sub>2</sub>O<sub>4</sub> without any significant decrease in the current or potential value in ORR and OER. …”
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Decomposition-based wind power forecasting models and their boundary issue: An in-depth review and comprehensive discussion on potential solutions
Published 2022“…Decomposition-based hybrid models have gained significant popularity in recent years. These methods generally disaggregate the original time series data into sub-time-series with better stationarity, and then the target data is predicted based on the sub-series. …”
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Development and Validation of a Class Imbalance-Resilient Cardiac Arrest Prediction Framework Incorporating Multiscale Aggregation, ICA and Explainability
Published 2025“…<p dir="ltr">Objective: Despite advancements in artificial intelligence (AI) for predicting cardiac arrest (CA) with multivariate time-series vital signs data, existing models continue to face significant problems, particularly concerning balance, efficiency, accuracy, and explainability. …”
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A novel hybrid methodology for fault diagnosis of wind energy conversion systems
Published 2023“…Feature selection pre-processing is an important step to increase the accuracy of the classification algorithm and decrease the dimensionality of a dataset. …”