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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
Published 2024“…Rapid urbanization primarily converts naturally vegetated areas and pervious surfaces into impervious built-up areas, significantly transforming microclimates and ecological dynamics. …”
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Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
Published 2024“…<p>Rapid urbanization primarily converts naturally vegetated areas and pervious surfaces into impervious built-up areas, significantly transforming microclimates and ecological dynamics. …”
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Pyrolysis of biosolids with waste cardboard: effect of operating parameters, feedstock size and blending ratio
Published 2023“…Proximate and ultimate analyses, metal composition, surface area, and surface charge studies were conducted on biochar samples utilizing analytical instruments. …”
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Estimation of Above-Ground Carbon-Stocks for Urban Greeneries in Arid Areas: Case Study for Doha and FIFA World Cup Qatar 2022
Published 2021“…<p>Urban areas are significant sources of anthropogenic carbon dioxide (CO<sub>2</sub>), which elevates air pollution. …”
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Published 2021“…<h3>Background</h3><p dir="ltr">Human immunodeficiency virus (HIV) remains a public health priority in Latin America. While the burden of HIV is historically concentrated in urban areas and high-risk groups, subnational estimates that cover multiple countries and years are missing. …”
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Unveiling the Nexus Between Land Use, Land Surface Temperature, and Carbon Footprint: A Multi-Scale Analysis of Building Energy Consumption in Arid Urban Areas
Published 2024“…Villas and commercial buildings exhibited the highest CF during the summer due to increased cooling demands, with noticeable CF hotspots in specific urban areas. …”
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Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov...
Published 2023“…At the 7th month, there was a significant decline in antibody responses among VN individuals, but not NI individuals, with a minimum decrease of 3.7-fold (p < 0.001). …”
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