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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
Published 2021“…The analysis focuses on the relation between EB ranges (battery capacity) and required charging rates (in kW) on the size of the fleet needed to cover a public transport timetable. The results of the conducted computational experiments indicate that an increase in infrastructure investment through high speed chargers can significantly decrease the size of the necessary fleets. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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The impact of stakeholder integration on large-scale, innovative PPP infrastructure projects
Published 2020“…In addition, this empirical study focused on SI in large-scale innovative infrastructure PPP projects, which will fill the gap of defining the impact and the importance of SI in these fields. …”
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Large scale synthesis of hexagonal boron nitride nanosheets and their use in thermally conductive polyethylene nanocomposites
Published 2023“…In this study, a large-scale synthesis of hBNNs via a ball milling (BM) technique is reported. …”
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A Methodology of Rule Discovery from Large-scale Multi-tier Noisy Educational Data
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Enabling large-scale integration of electric bus fleets in harsh environments: Possibilities, potentials, and challenges
Published 2024“…Moreover, the grid impact of large-scale charging systems is identified and classified by identifying the factors affecting the grid hosting capacity and permissible interaction levels. …”
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Enabling large-scale integration of electric bus fleets in harsh environments: Possibilities, potentials, and challenges
Published 2024“…Moreover, the grid impact of large-scale charging systems is identified and classified by identifying the factors affecting the grid hosting capacity and permissible interaction levels. …”
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Comparative study of SPI success factors in global and in-house environment for large-scale software companies
Published 2023“…Still, less attention has been paid to the SPI success factors in the case of the GSD environment for large-scale software companies. Factors that contribute to the SPI success of small as well as medium-sized companies have been identified, but large-scale companies have still been overlooked. …”
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Parallel multi-voltage power minimization in VLSI circuits. (c2013)
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Benthic development on large-scale engineered reefs: a comparison of communities among breakwaters of different age and natural reefs
Published 2011“…Breakwaters represent large-scale engineered artificial reefs that can develop diverse and abundant communities and are likely to play an increasing role in marine ecosystems as human populations grow in coastal urban areas. …”
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