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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Enhancing Urban Connectivity and Regeneration of Historic Areas: Case Study of Heart of Sharjah
Published 2020“…A unique and significant historical district in Sharjah called ‘Heart of Sharjah’ is analyzed and assessed in terms of its livability and connectivity through a resilient urban framework. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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A Probabilistic and Traffic-Aware Bundle Release Scheme for Vehicular Intermittently Connected Networks
Published 2012“…In this context, the design of effective delay-minimal data relaying strategies is receiving significant attention. However, many existing such schemes either do not adequately model vehicular traffic behaviours or adapt typical Internet packet-like forwarding protocols to VICNs. …”
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Emotion Recognition Based on Fusion of Local Cortical Activations and Dynamic Functional Networks Connectivity: An EEG Study
Published 2019“…We estimate the cortical activations using power spectral density (PSD) with the Burg autoregressive model. On the other hand, we estimate the functional connectivity networks by utilizing the phase locking value (PLV). …”
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LSCS-Net: A lightweight skin cancer segmentation network with densely connected multi-rate atrous convolution
Published 2024“…The integration of modern computer vision methods into clinical procedures offers the potential for enhancing the detection of skin cancer . The UNet model has gained prominence as a valuable tool for this objective, continuously evolving to tackle the difficulties associated with the inherent diversity of dermatological images. …”
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Interval-Valued Reduced Ensemble Learning Based Fault Detection and Diagnosis Techniques for Uncertain Grid-Connected PV Systems
Published 2022“…The IKPCA-EL techniques are addressed so that the features extraction and selection phases are performed using the IKPCA models and the sensitive and significant interval-valued characteristics are transmitted to the EL model for classification purposes. …”
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Shared Clean Mobility Operations for First-Mile and Last-Mile Public Transit Connections: A Case Study of Doha, Qatar
Published 2022“…We propose an integrated route choice and EV assignment model to address the potential of car-sharing services as a feeder to the public transit network. …”
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Assessment of Brain Function After 240 Days Confinement Using Functional Near Infrared Spectroscopy
Published 2024“…The FCN shows a significant decrease in most of the right frontal areas. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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The behavior of Tapered High Strength Concrete Filled Steel Tube (CFST) Column connected to Encased Steel Reinforced Concrete Composite (SRC) Column
Published 2020“…This research is focusing on the behavior of a tapered concrete filled steel tube column (CFST) connected to encased composite column (SRC). The purpose of having two different sections along the column height is to enhance the flexure resistance of the column at the top edge by introducing CFST element, while the lower part is modeled as SRC element and it is mainly subjected to axial compression with significant reduction in bending moments compared to the top part of the column. …”
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