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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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An Evaluation of Short-Term Effects of Different Soil Management Systems on Soil Physical, Structural and Hydraulic Properties and an Estimation and Optimization of Water Infiltrat...
Published 2022“…For irrigation rate smaller than 0.05cm/min, NT was faster since all the other systems had larger pore structure for which more time is needed to saturate. For higher irrigation rates, systems have only tilled layer are more efficient especially those amalgamated with chicken manure. …”
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The Mathematical Modeling, Diffusivity, Energy, and Enviro-Economic Analysis (MD3E) of an Automatic Solar Dryer for Drying Date Fruits
Published 2024“…Among the twelve thin-layer mathematical models, we chose the best thin drying model based on a higher R<sup>2</sup> and lower χ<sup>2</sup> and RMSE. …”
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Strengthening of thin reinforced concrete slabs with CFRP laminates
Published 2016“…The preliminary results from this study have shown that, the thin RC slabs can carry significantly higher loads in buildings if externally strengthened with CFRP laminates. …”
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Formability of Ultrasonically Additive Manufactured Ti-Al Thin Foil Laminates
Published 2019“…Hydraulic bulge test results showed that elongation improved as the number of bi-layers increased, yet the ultimate strength values did not change significantly indicating an expansion of the formability window.…”
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Formability of Ultrasonically Additive Manufactured Ti-Al Thin Foil Laminates
Published 2019“…Hydraulic bulge test results showed that elongation improved as the number of bi-layers increased, yet the ultimate strength values did not change significantly indicating an expansion of the formability window.…”
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The impact of cost function globality and locality in hybrid quantum neural networks on NISQ devices
Published 2023“…We consider two application scenarios namely, binary and multi-class classification, and show that for multiclass classification, the local cost function setting does not follow the claims of Cerezo et al; that is, the local cost function does not result in an extended quantum layer’s depth. We also show that for multiclass classification, the overall performance in terms of accuracy for the global cost function setting is significantly higher than the local cost function setting. …”
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Preparation of Mesoporous/Microporous MnCo<sub>2</sub>O<sub>4</sub> and Nanocubic MnCr<sub>2</sub>O<sub>4</sub> Using a Single Step Solution Combustion Synthesis for Bifunction Oxy...
Published 2020“…Chronoamperometric (CA) runs for 24 h shows excellent stability of MnCo<sub>2</sub>O<sub>4</sub> without any significant decrease in the current or potential value in ORR and OER. …”
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The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer
Published 2020“…HuArgI (Co)-PEG5000 is a potential drug to target cancers that depend on exogenous sources of arginine and cannot synthesize their own. In this study, we hypothesized that HuArgI (Co)- PEG5000 can decrease the migration of ovarian cancer cells. …”
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Bond durability of sand coated and ribbed basalt FRP bars embedded in high-strength concrete
Published 2023“…However, specimens with high-strength concrete achieved most of or above their maximum bond strength after the descending stage, while those with normal-strength concrete showed a decrease in bond strength to an approximately constant value with continuous slip. Ribbed bars had significantly higher bond strength than sand-coated bars and were less affected by the surrounding environments. …”
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The Effect of Recombinant Anthrax Lethal Toxin on Breast Cancer Cell Motility, Adhesion, and Invasion
Published 2020“…Cells treated with LT showed a significant decrease in motility as seen in 2D time-lapse and wound healing assays. …”
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masterThesis