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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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A systematic review of Arabic text classification: areas, applications, and future directions
Published 2023“…The selected studies were divided into three categories: topic areas, tasks/applications, and ATC phases. The topic areas were classified into six primary sectors: healthcare, legal, security and cybersecurity, history, culture and religion, social media, and agriculture. …”
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Ground subsidence monitoring with SAR interferometry techniques in the rural area of Al Wagan, UAE
Published 2018“…The quantification of ground deformations of large magnitude and small amplitude in this area with SAR Interferometry is a challenging task using moderate resolution data due to the incoherent surface background. …”
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Adaptive response for climate change challenges for small and vulnerable coastal area (SVCA) countries: Qatar perspective
Published 2023“…Long-term mitigation efforts would not help them reduce their current or immediate vulnerability in the short-term, as long as large countries with comparably huge populations, economies, heavy industrial dependences, and extreme consumption levels do not change their courses significantly. …”
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Enabling large-scale integration of electric bus fleets in harsh environments: Possibilities, potentials, and challenges
Published 2024“…This paper presents a comprehensive and detailed investigation of electric bus transit systems, focusing on their feasibility in harsh environmental areas. The aspects that combine economics, operation, long-term performance, and reliability are all addressed and discussed in both short and long-term horizons. …”
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Enabling large-scale integration of electric bus fleets in harsh environments: Possibilities, potentials, and challenges
Published 2024“…<p>This paper presents a comprehensive and detailed investigation of electric bus transit systems, focusing on their feasibility in harsh environmental areas. The aspects that combine economics, operation, long-term performance, and reliability are all addressed and discussed in both short and long-term horizons. …”
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Parallel multi-voltage power minimization in VLSI circuits. (c2013)
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Benthic development on large-scale engineered reefs: a comparison of communities among breakwaters of different age and natural reefs
Published 2011“…Breakwaters represent large-scale engineered artificial reefs that can develop diverse and abundant communities and are likely to play an increasing role in marine ecosystems as human populations grow in coastal urban areas. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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KT2C. (c2014)
Published 2016“…The temperature profile of the resulting chip is calculated using the thermal simulator “Hotspot” and is compared to the temperature profile of a design achieved using a regular design flow. The results show significant reduction in both average and peak temperatures at the cost of a small increase in area. …”
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