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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Government Data Governance and Management Frameworks Positive Collaborations, to Enhance Data Sharing and Efficiency of Government Services in Smart Cities
Published 2018“…These cities value up the citizens prospective through services focused on innovation driven and data sharing; consequently, or in simple words embarking and enabling data sharing and offer smart services across the city. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Knowledge Fusion by Harnessing Support Vector Machines for Collaborative Uncertain Data Classification in Multiagent Systems
Published 2024“…Distributed data mining (DDM) has emerged as a useful method for analyzing data that is spread across multiple sources. Nevertheless, DDM has other challenges that restrict its effectiveness, such as autonomy, privacy, efficiency, and implementation. …”
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QNL and HERMES Project: Impact Stories
Published 2024“…<p dir="ltr">The presentation highlights the involvement of QNL’s ILDS section in the HERMES project and its significant impact on daily operations, users, and cost savings. …”
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Interlending and Document Supply Services at Qatar National Library: A Focus on Multicultural Patron Engagement and Enhancement
Published 2024“…Analysis reveals the distribution of patrons across various institutions, with a concentration from educational and professional sectors. …”
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Diversity of protists in dryland habitats of Qatar revealed by environmental metabarcoding
Published 2025“…Across all samples, 170 genera were identified, of which 52 were shared across all sites. …”
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Paraphrasing Arabiuc Metaphor with Neural Machine Translation
Published 2018“…Experimental ntal results across datasets confirm that neural paraphrases significantly outperform those obtained with…”
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The Impact of School Leaders and Teachers in Empowering Students Towards NWEA MAP Assessment Attainment: A Study in a Private School in Dubai
Published 2024“…Additionally, increased access to technology platforms also played a significant role and improved performance. Nevertheless, the study's limitation to one school indicates that further research across diverse educational settings is necessary for generalizability. …”
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Neural Machine Translation for Arabic Language
Published 2019“…Experimental results across datasets confirm that neural paraphrases significantly outperform those obtained with statistical machine translation, and indicate high similarity correlation between our model and human translation, making our model attractive for real-world deployment.…”
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The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer
Published 2020“…HuArgI (Co)-PEG5000 is a potential drug to target cancers that depend on exogenous sources of arginine and cannot synthesize their own. In this study, we hypothesized that HuArgI (Co)- PEG5000 can decrease the migration of ovarian cancer cells. …”
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