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Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
Published 2020“…Here, we used bisulfite pyrosequencing and show that methylation of the rDNA transcription unit including upstream control element (UCE), core promoter, 18S rDNA, and 28S rDNA in human sperm also significantly increases with donor's age. This positive correlation between sperm rDNA methylation and biological age is evolutionarily conserved among mammals with widely different life spans such as humans, marmoset, bovine, and mouse. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Published 2021“…</p><h3>Conclusions</h3><p dir="ltr">Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. …”
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Deep aging clocks: AI-powered strategies for biological age estimation
Published 2025“…<p>Several strategies have emerged lately in response to the rapid increase in the aging population to enhance health and life span and manage aging challenges. …”
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Hedonic valuation of land protection methods: implications for cluster development.
Published 2014“…The key findings of the study are: (i) proximity to national or state park land and to city or county open space has a significant positive impact on property values, while proximity to national forest land or to privately conserved land exhibits no significant effects; and, (ii) inclusion of a property within a cluster development decreases its value by 17 to 26 %. …”
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Aging Effects in Field-Compacted Dredged Material
Published 2013“…The addition of SSF to the 100% DM resulted in significant pH buffering and in strength increases up to a factor of 2, as measured by the average cone penetrometer test (CPT) tip resistance. …”
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Perinatal factors impacting echocardiographic left ventricular measurement in small for gestational age infants: a prospective cohort study
Published 2023“…<h2>Introduction</h2><p dir="ltr">Infants born small for gestational age (SGA) have an increased risk of developing various cardiovascular complications. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Association between Healthy Lifestyle Index and Cognitive decline In Community- Dwelling Lebanese Older Adults
Published 2021“…Objective: Normal aging is often associated with cognitive deterioration in older adults, but the prevalence of cognitive decline like cognitive impairment, Alzheimer’s disease and dementia has been increasing lately. …”
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Crisis Management and Crisis Communication in the Digital Age: The Impact of Social Media
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Effect of consanguinity on birth weight for gestational age in a developing country
Published 2007“…After controlling for medical and sociodemographic covariates, the authors found a statistically significant negative association between consanguinity and birth weight at each gestational age. …”
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Health Care Accessibility of Lebanese Working-Age Adults with Musculoskeletal Disability
Published 2016“…The diversity of the Lebanese society increased after the 1975-1990 civil war, the grapes of Wrath conflict and July 2006 war. …”
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Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism
Published 2023“…<p dir="ltr">Children from old fathers carry an increased risk for autism spectrum (ASD) and other neurodevelopmental disorders, which may at least partially be mediated by paternal age effects on the sperm epigenome. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis
Published 2023“…In addition, a combination of other comorbidities and old age appears to increase the risk of mortality from COVID-19.…”
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Impact of body composition analysis on male sexual function: A metabolic age study
Published 2023“…Although erectile dysfunction (ED) and hypogonadism are increasingly prevalent with age, they are also detected among younger men. …”
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Benthic development on large-scale engineered reefs: a comparison of communities among breakwaters of different age and natural reefs
Published 2011“…Multivariate analyses indicated that benthic communities on breakwaters became more similar to natural reefs with increasing age, but that communities on even the most mature (31 years) breakwater were distinct from those on natural reefs (ANOSIM p < 0.001). …”
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