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Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping
Published 2024“…</i>) where we quantify over 18,000 unique peptides from nearly 3000 proteins in more than 320 blood samples from a multi-ethnic cohort in a bottom-up, peptide-centric, mass spectrometry-based proteomics approach. We identify 184 protein-altering variants in 137 genes that are significantly associated with their corresponding variant peptides, confirming target specificity of co-associated affinity binders, identifying putatively causal cis-encoded proteins and providing experimental evidence for their presence in blood, including proteins that may be inaccessible to affinity-based proteomics.…”
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Significance of Avicennia Marina in the Arabian Gulf Environment: A Review
Published 2025“…However, in the past two decades Gulf mangroves have been facing significant threats, including extensive coastal development, shoreline modification by establishing marinas and ports, and climate change-associated impacts such as sea-level rise and altered precipitation patterns, which pose significant risks to this fragile ecosystem. …”
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Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition: a validation study
Published 2024“…Pathway analysis of significantly altered metabolites in the validation set revealed that they are involved in branched-chain amino acids (BCAAs) and energy metabolism (glycolysis and gluconeogenesis). …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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The impact of maternal care on child development
Published 2019“…Studying heterogeneous effects reveals a differential impact by child's age. An increase of 6.5 h per week in the time 2-year-olds spend with their mothers significantly improves their non-cognitive skills.…”
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Application of surfactants in enhancing oil recovery from tight carbonates: Physicochemical properties and core flooding experiments
Published 2023“…It was shown that the presence of the surfactants and the increase in salinity both caused a significant reduction in the oil-water IFT. Additionally, all surfactant formulations altered the wettability of carbonate rock from intermediate-to water-wet conditions. …”
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The Impact of Employee Engagement on Turnover Intention and Burnout
Published 2021“…Employee engagement has been the center of attention for a long period because of the significant positive impact that it exerts on work-related outcomes of employees. …”
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Unpacking the asymmetric impact of exchange rate volatility on trade flows: A study of selected developed and developing Asian economies
Published 2023“…The non-linear models yielded more significant findings, while the linear models did not indicate any significant effects of exchange rate volatility on trade flows. …”
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The synergistic effects of cationic surfactant and smart seawater on the recovery of medium-viscosity crude oil from low-permeability carbonates
Published 2023“…The use of smart SW and CTAB significantly altered the wettability of carbonate rock towards water-wet and reduced the interfacial tension (IFT) between crude oil and water, reaching levels below 0.087 mN/m. …”
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The Impact of the 2019 Lebanese Multidimensional Crisis on Young Adults’ Political Attitudes and Behavior
Published 2022“…Findings show that the 2019 multidimensional crisis had a significant negative impact on young adults’ political attitudes and behavior, affecting their affiliations, political interest, and trust. …”
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3D Concrete Printing Sustainability: A Comparative Life Cycle Assessment of Four Construction Method Scenarios
Published 2020“…Moreover, the use of an alternative concrete mixture in 3DCP showed a further decrease in the GWP, AP, EP, and FFD impact. Ultimately, the findings in this paper support the advantages of 3DCP technology and recommend the investigation of the development of (i) sustainable printable concrete materials and (ii) novel reinforcement techniques that are suitable for 3DCP rather than adopting conventional reinforcement techniques.…”
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
Published 2010“…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …”
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Impact of the positive pressure valve on vascular access device occlusions and bloodstream infections
Published 2009“…These types of devices have been shown to significantly decrease VAD occlusion rates by 8.2%, when compared to a standard connector device (Jacobs et al., 2004). …”
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The Impacts of COVID-19 on the Well-Being of students with SEN in Primary Stage in Dubai Schools
Published 2022“…Findings indicated a decrease in the levels of well-being among the study sample as a result of their Well-being affected by the pandemic, while there were no statistically significant differences between the various disabilities ( learning difficulties - hyperactivity - hearing impairment - visual impairment - mild speech disorder) in their average levels of well-being, while it became clear that there are some differences between males and females in the average Well-being scores in favour of males, and their average Well-being scores were high compared to females. …”
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Synthetic Cannabinoid AB-FUBINACA Negatively Impacted the Male Fertility and Induced Testicular Toxicity
Published 2025“…AB-FUBINACA treatment also causes a significant dose related decrease in sperm viability. …”
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