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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Detection of statistically significant network changes in complex biological networks
Published 2017“…</p><h3>Methods</h3><p dir="ltr">In this paper, we propose an improvement over the state-of-the-art based on the Generalized Hamming Distance adopted for evaluating the topological difference between two networks and estimating its statistical significance. The proposed procedure exploits a more effective model selection criteria to generate <i>p</i>-values for statistical significance and is more efficient in terms of computational time and prediction accuracy than literature methods. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Distribution network line protection in the presence of distributed generation
Published 2015“…Unlike synchronous and asynchronous generators, inverter based DGs have a controlled current output during faults. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Feeder protection challenges with high penetration of inverter based distributed generation
Published 2013“…The paper discusses the challenges for the protection system related to the integration of increasingly significant amounts of DG and highlights the need for more sophisticated protection systems.…”
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Distributed generator status estimation for adaptive feeder protection in active distribution grids
Published 2013“…This paper proposes a framework for adaptive feeder protection in distribution grids with a high amount of distributed generators (DGs) installed. …”
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Assessing the potential of network reconfiguration to improve distributed generation hosting capacity in active distribution systems
Published 2014“…As the amount of distributed generation (DG) is growing worldwide, the need to increase the hosting capacity of distribution systems without reinforcements is becoming nowadays a major concern. …”
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An overview of future sustainable nuclear power reactors
Published 2013“…In particular, the nuclear technology is described and the classification of the current and future nuclear reactors according to their generation is provided. The analysis has shown that generation II reactors currently in operation all around the world lack significantly in safety precautions and are prone to loss of coolant accident (LOCA). …”
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An Optimal Energy Dispatch Management System for Hybrid Power Plants: PV-Grid-Battery-Diesel Generator-Pumped Hydro Storage
Published 2024“…The cost of CO<sub>2</sub> emissions was found to be lower in the case of SDDP, amounting to 8.3 $ /24h for a total emission of 160 kg. …”
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Effective generation of functional pancreatic β-cells from human derived dental stem cells of apical papilla and bone marrow derived stem cells
Published 2023“…Next, the maturity and functionality of the differentiated cells was evaluated by measuring the amount of insulin and C-peptide secreted by the derived ICAs using ELISA. …”
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
Published 2017“…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …”
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Impact of Using Recycled Materials in the Construction Industry of the United Arab Emirates
Published 2015“…The main barrier to the achievement of sustainability relates to the increasing levels of wastes generated in the industry. The increased concerns about the amount of construction and demolition (C&D) waste generated in the country has led to different groups calling for increased recycling of the waste rather than disposal in landfills. …”
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