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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Exploring the Significance of Publication-Age-Based Parameters for Evaluating Researcher Impact
Published 2023“…Currently, the state-of-the-art evaluation of these indices is based on hypothetical scenarios and the limited and unfair distribution of researcher records in the datasets. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Students’ perceptions of Kahoot!: An exploratory mixed-method study in EFL undergraduate classrooms in the UAE
Published 2021“…In recent years, game-based student response systems (GSRS) such as Socrative, Quizlet, and Kahoot! …”
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Comparing the effectiveness of concept-based curricula and video-based curricula in ESL primary classrooms
Published 2022“…Outcomes: The findings from this study demonstrate that the students who studied using video-based learning as a learning approach, accompanied by discussion, performed significantly better than those who studied with concept-based learning in understanding English language grammar. …”
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The Play-based Behaviours of Emirati Preschool Children: Cultural Perspective into Early Childhood Education
Published 2020“…Results revealed that 52% of Emirati children rarely or never engage in undirected play and that while Emirati mothers were aware of the significance of play, they were less aware of “child-led” play practices, how to facilitate undirected play at home and the significance of their role in scaffolding play. …”
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Aspect-based sentiment analysis using smart government review data
Published 2019“…According to the reported results, the aspect extraction accuracy improves significantly when the implicit aspects are considered. …”
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Treating Cancers Using Nature’s Medicine: Significance and Challenges
Published 2021“…In recent decades, the emphasis on identifying therapeutic plant-based active principles led to significant advancements in the identification and use of natural compounds to treat various diseases (Figure 1) [2,3]. …”
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The Impact of Inquiry-based Learning on the Critical Thinking of high School Students
Published 2021“…Explanatory sequential mixed-methods approach was utilized in the current study in which the data are collected and analyzed quantitatively first, and then qualitative data were collected in order to fully explain the quantitative data results The current study found that inquiry-based learning approach has a statistically significant positive impact on the high school students’ critical thinking in where the independent T-test results were for t (90) = 7 with a P value equals to 0.000 ˂ 0.05. …”
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LCMV-Based EEG & FNIRS-Based Brain Source Localization of Mental Stress
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Maternal secure base support and preschoolers' secure base behavior in natural environments
Published 2007“…Overall, findings indicated that maternal secure base support was significantly related to the organization of child secure base behavior (r = .31 and .49 for Study 1 and Study 2, respectively). …”
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