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decrease » increase (Expand Search)
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Coevolving residues distant from the ligand binding site are involved in GAF domain function
Published 2025“…<p dir="ltr">Ligand binding to GAF domains regulates the activity of associated catalytic domains in various proteins, such as the cGMP-hydrolyzing catalytic domain of phosphodiesterase 5 (PDE5) activated by cGMP binding to GAFa domain. …”
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Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model
Published 2022“…Furthermore, heart transcriptome profiling showed a significant downregulation of the actin-filament-based process, indicating an impaired actin cytoskeleton organization as the main dysregulating factor associated with the early ventricular cardiac hypertrophy in the zebrafish mypbc3 HCM model.…”
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Mixed precision iterative refinement with adaptive precision sparse approximate inverse preconditioning
Published 2025“…<p dir="ltr">Hardware trends have motivated the development of mixed precision algorithms in numerical linear algebra, which aim to decrease runtime while maintaining acceptable accuracy. …”
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
Published 2019“…Specifically, symptom queries were first determined to be significantly predictive of subsequent 12-step queries if the probability of querying a medical symptom by those who later sought information about the 12-step program exceeded the probability of that same query being made by a comparison group of all other Bing users in the United States. …”
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Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women
Published 2021“…In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. In conclusion, serum 25-hydroxyvitamin D was inversely associated with adiposity measures and non-linearly associated to bone mass in postmenopausal Qatari women.…”
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Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women
Published 2021“…In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. In conclusion, serum 25-hydroxyvitamin D was inversely associated with adiposity measures and non-linearly associated to bone mass in postmenopausal Qatari women.…”
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Analyzing the Influence of Climate and Anthropogenic Development on Vegetation Cover in the Coastal Ecosystems of GCC
Published 2025“…Our results revealed significant changes in land cover, as seen by an increase in artificial built-up areas by 15.5% in two decades and a corresponding decrease in bareland and dense vegetation. …”
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Preterm birth in low-middle income Countries
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Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping
Published 2024“…Most previous work has been conducted using affinity-based proteomics approaches. These technologies face challenges, such as uncertainty regarding target identity, non-specific binding, and handling of variants that affect epitope affinity binding. …”
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Efficient mechanochemical synthesis of new fluorinated Schiff bases: a solvent-free, alternative to conventional method with mercury adsorption properties
Published 2025“…The synthesized fluorinated Schiff bases are evaluated for their adsorption capacity and efficiency in mercury removal and compared to assess their performance, demonstrating that ball milling produced compounds with comparable physical attributes to those produced via traditional solvent-based procedures. …”
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Computational identification of genetic subnetwork modules associated with maize defense response to Fusarium verticillioides
Published 2015“…The other two predicted modules were indirectly involved in the defense response, where the most significant GO terms associated with these modules were GO:0046914 (transition metal ion binding) and GO:0046686 (response to cadmium ion). …”
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SARS‐CoV‐2 infection triggers more potent antibody‐dependent cellular cytotoxicity (ADCC) responses than mRNA‐, vector‐, and inactivated virus‐based COVID‐19 vaccines
Published 2024“…Although post‐mRNA vaccination BTI elicited high levels of binding and NAbs, ADCC activity was significantly reduced. …”
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A novel hybrid methodology for fault diagnosis of wind energy conversion systems
Published 2023“…Feature selection pre-processing is an important step to increase the accuracy of the classification algorithm and decrease the dimensionality of a dataset. …”
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Effect of consanguinity on birth weight for gestational age in a developing country
Published 2007“…No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. …”
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Structure-guided engineering and molecular simulations to design a potent monoclonal antibody to target aP2 antigen for adaptive immune response instigation against type 2 diabetes
Published 2024“…This approach involved screening a mutational landscape comprising 57 mutants to identify modifications that yield significant enhancements in binding efficacy and stability.…”
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Do near-bedtime usage of smartphones and problematic internet usage really impact sleep? A study based on objectively recorded usage data
Published 2023“…Regarding sleep distraction, multivariate linear regression analysis revealed that two hours before sleep was a significant and positive predictor of sleep distraction (β = 0.197, p = 0.003), whereas PIU was not significant. …”
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A GRASP Approach for Solving Large-Scale Electric Bus Scheduling Problems
Published 2021“…The results of the conducted computational experiments indicate that an increase in infrastructure investment through high speed chargers can significantly decrease the size of the necessary fleets. …”