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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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LCMV-Based EEG & FNIRS-Based Brain Source Localization of Mental Stress
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Oral contraceptive pills and possible adverse effects
Published 2014“…Since their introduction to the market, there have been significant changes in the drug content and formulations of these products, in part to decrease the risk of adverse effects. …”
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Kernel-Ridge-Regression-Based Randomized Network for Brain Age Classification and Estimation
Published 2024“…Moreover, the proposed algorithm demonstrated excellent prediction accuracy with a mean absolute error (MAE) of <b>3.89</b> years, <b>3.64 </b>years, and <b>4.49</b> years for GM, WM, and CSF regions, confirming that changes in WM volume are significantly associated with normal brain aging. Additionally, voxel-based morphometry (VBM) examines age-related anatomical alterations in different brain regions in GM, WM, and CSF tissue volumes.…”
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Brain Region-Based Vigilance Assessment Using Electroencephalography and Eye Tracking Data Fusion
Published 2022“…The overall results showed that vigilance is a brain region specific and the fusion of EEG+and Eye tracking data using CCA has significantly improved the classification accuracy of vigilance levels assessment.…”
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
Published 2010“…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …”
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An Efficient Brain Tumor Segmentation Method Based on Adaptive Moving Self-Organizing Map and Fuzzy K-Mean Clustering
Published 2023“…<p dir="ltr">Brain tumors in Magnetic resonance image segmentation is challenging research. …”
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Brain Connectivity Analysis Under Semantic Vigilance and Enhanced Mental States
Published 2019“…BRMUS factors, such as fatigue, depression, and anger, significantly decrease in the enhancement group compared to vigilance group. …”
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The outcome of severe traumatic brain injury in children in Qatar: Six-year study
Published 2015“…The Glasgow Coma Scale (GCS) was used to assess severity of TBIs. This study was based on 65 children suffering from severe traumatic brain injury, of which 12 of them died within the first month of admission in pediatric intensive care unit. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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