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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Artificial intelligence based anomaly detection of energy consumption in buildings: A review, current trends and new perspectives
Published 2021“…In this regard, this paper is an in-depth review of existing anomaly detection frameworks for building energy consumption based on artificial intelligence. …”
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GIS-BIM Based Regional Seismic Risk Assessment for Dubai, UAE
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Urban Geometry: The Effect of Height Diversity and Buildings Configuration on Thermal Performance and Cooling Load at Urban Scale. A Case Study in Dubai / UAE
Published 2018“…The research found that a significant variation in building height reduces the cooling load more than a gradual height variation, and consequently offers more energy saving. …”
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Calibration of building model based on indoor temperature for overheating assessment using genetic algorithm: Methodology, evaluation criteria, and case study
Published 2022“…This methodology includes a variance-based sensitivity analysis to determine building parameters that significantly influence indoor air temperatures, the Multi-Objective Genetic Algorithm to calibrate different rooms simultaneously based on the significant param eters identified by the sensitivity analysis, and new evaluation criteria to achieve a high-accuracy calibrated model. …”
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Get full text
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Empowering resettled child and adolescent refugees through school-based mental health programs: Building a more inclusive community
Published 2023“…This article aims to highlight the significance of school-based mental health initiatives in fostering a safe, nurturing environment that enables young refugees to build the resilience required to function effectively in the longer term.…”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”