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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Compassionate care in nursing: The role of simulation-based compassionate care on nurse's caring behavior, self-efficacy and compassion competency
Published 2025“…In contrast, the control group showed minimal changes across these domains, with p-values indicating no significant differences. </p><h3 dir="ltr">Conclusion</h3><p dir="ltr">The findings highlight the effectiveness of simulation-based compassionate care training in enhancing nurses' caregiving behaviors, self-efficacy and compassionate competence. …”
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Stigma against health care providers caring for COVID-19 patients in Turkey
Published 2022“…<p dir="ltr">Health care providers (HCPs) worldwide have been a common target for stigmatization during widespread infections, such as COVID-19. …”
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Toward a Clearer Understanding of Value‐Based Healthcare: A Concept Analysis
Published 2025“…<h3>Background</h3><p dir="ltr"> Value‐based healthcare (VBHC) aims to improve the quality of healthcare delivery while reducing costs and also aims for outcomes that are of utmost importance from patients’ perspectives. …”
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Nursing Perception Towards Impact of JCI Accreditation and Quality of Care in a Tertiary Care Hospital, Central Saudi Arabia
Published 2014“…Hospital accreditation indicates meeting the highest international standards and requirements in the health care industry .Aims of this study are: 1) to assess nurses‟ perception to JCI accreditation impact, 2) to assess nurses‟ perception to quality of health care (QHC), and 3) to identify the predictive factors for perception to accreditation and QHC at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia. …”
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Curricular integration of the pharmacists' patient care process
Published 2021“…Results The findings indicate that the PPCP-based laboratory significantly improved students' perception of their preparedness to apply a standardized pharmacist care process to verify prescriptions, to collect relevant patient information, and to develop an individual patient-centered care plan. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Health conditions, health literacy, access to care, and health care experiences among lesbian, gay, bisexual, transgender and queer adults in Lebanon
Published 2025“…Background This study aims to assess the physical health of individuals belonging to the lesbian, gay, bisexual, transgender, and queer (LGBTQ) community, considering health system challenges like access to care and patient experiences and community-specific attributes like health literacy and self-acceptance. …”
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