The Cancer Spliceome: Reprograming of Alternative Splicing in Cancer by Ettaib El Marabti (23276158)

“…These isoforms and their encoded proteins are not insignificant byproducts of the abnormal physiology of cancer cells, but either drivers of cancer progression or small but significant contributors to specific cancer hallmarks. …”

A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…<p dir="ltr">NanoLuc (NLuc) <u>luciferase</u> has found extensive application in designing a range of <u>biologica</u><u>l</u><u> assays,</u> including <u>gene expression analysis</u>, protein-protein interaction, and protein conformational changes due to its enhanced brightness and small size. …”

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”

Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells by Queenie, Fernandes

“…Cancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. …”
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Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells by Queenie Fernandes (14557388)

“…<p>Cancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. …”

Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion by Khoury, Nathalie

“…The expression of certain genes involved in proliferation and apoptosis was measured using reverse transcriptase‑polymerase chain reaction (RT‑PCR) and western blotting. …”
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Anti-cancer Evaluation of Lebanese Cannabis Oil Extract on Lung and Breast Cancer Cells by Saliba, Jane

“…Cell viability was evaluated using MTS cell proliferation assay and COE demonstrated more selectivity against MDA-MB-231 (IC50 =26.7 μg/mL) and A549 (IC50 =30.2 μg/mL), compared to rat stem cells (IC50 =42.31 μg/mL). COE caused more significant cell migration inhibition in A549 cells than MDA-MB-231 cells. …”
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Targeting cancer signaling pathways by natural products: Exploring promising anti-cancer agents by Sheema Hashem (14150961)

“…<p>Cancer is one of the leading causes of death and significantly burdens the healthcare system. …”

Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk by Merhi, Mahmoud

“…Moreover, a significant smoking-gene interaction is determined with CYP1A1 MspI polymorphism rs4646903 and is associated with a decreased risk of CAD in current smokers (OR 0.52137). …”
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The anti-cancer effect of series of strained photoactivatable Ru(II) polypyridyl complexes on non-small-cell lung cancer and triple negative breast cancer cells by Fayad, Christelle

“…Upon light activation, C3 caused significant ROS production and induced apoptosis in MDA-MB-231 cells as shown by flow cytometry. …”
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Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications by Jingxuan Shan (4711089)

“…We found a highly significant association between the <b><i>CCND1</i></b><b> </b><b>rs614367-TT</b> genotype (OR = 5.14; <i>P</i> = 0.004) and TNBC risk, and identified a significant association between the <b>rs614367-T</b> allele and decreased PFS in TNBC. …”

STARD 13 in prostate cancer. (c2018) by Saab, Sahar S.

“…Prostate cancer is the most commonly diagnosed solid organ tumor and one of the main leading causes of death – due to cancerous tumors- among men in the world. …”
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Non-Invasive Biomarkers for Early Lung Cancer Detection by Harman Saman (16316283)

“…<p dir="ltr">Worldwide, lung cancer (LC) is the most common cause of cancer death, and any delay in the detection of new and relapsed disease serves as a major factor for a significant proportion of LC morbidity and mortality. …”

Natural products as chemo-radiation therapy sensitizers in cancers by Sabah Nisar (12561961)

“…<p dir="ltr">Cancer is a devastating disease and is the second leading cause of death worldwide. …”

Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through... by Masri, Oussama Samer

“…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …”
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Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients by Esraa K. Al-Amleh (16023071)

“…Platelet counts, on the other hand, dramatically decreased in both IM and (HU + IM).</p><h3>Conclusion</h3><p dir="ltr">Because the studied genes (BCL2, PP2A, CIP2A, and WT1) are participating in cell proliferation and death, the findings show that the examined genes are significant to understand the efficacy of various therapies. …”

Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer by Iqra Attique (21493444)

“…Cancer cells typically exhibit elevated ROS levels due to disrupted redox homeostasis, characterized by an imbalance between antioxidant and oxidant species. …”

Use of deep vein thrombosis prophylaxis in hospitalized cancer patients by Awar, Zeina

“…Venous thromboembolism is a common complication and a major cause of morbidity and mortality in cancer patients. …”
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Mammary adipose dysfunction in the dual epidemic of obesity and breast cancer by Elvina Jeyakumar (22997311)

“…<p dir="ltr">Breast cancer (BC) is one of the leading causes of death among women, with obesity being a significant factor. …”

Snake venom in conjugation with silica nanoparticles: an emerging cancer therapy by Duaa Azam (22502048)

“…<p dir="ltr">Cancer remains one of the most prevalent causes of mortality worldwide and thus necessitates the development of novel therapeutic strategies. …”