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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Published 2021“…</p><h3>Conclusions</h3><p dir="ltr">Our subnational estimates of HIV mortality revealed significant spatial variation and diverging local trends in HIV mortality over time and by age. …”
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Multi-IsnadSet MIS for Sahih Muslim Hadith with chain of narrators, based on multiple ISNAD
Published 2024“…The graph representation of the authentic and manually curated dataset will open ways for the development of computational models that could identify the significance of a chain and a narrator. The dataset allows the researchers to provide Hadith narrators and Hadith ISNAD that could be used in a wide variety of future research studies related to Hadith authentication and rules extraction. …”
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Hedonic valuation of land protection methods: implications for cluster development.
Published 2014“…The key findings of the study are: (i) proximity to national or state park land and to city or county open space has a significant positive impact on property values, while proximity to national forest land or to privately conserved land exhibits no significant effects; and, (ii) inclusion of a property within a cluster development decreases its value by 17 to 26 %. …”
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QFD-based optimization model for mitigating sustainable supply chain management adoption challenges for Bangladeshi RMG industries
Published 2024“…The optimal solution incorporates green strategies, technology integration, and aspects of Industry 5.0, demonstrating a holistic approach to sustainable supply chain management. The findings are crucial for Bangladeshi RMG industries aiming for global market competitiveness and contribute significantly to the academic field by introducing a robust, data-driven decisions for sustainable supply chain optimization. …”
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Security Supply Chain Using UAVs: Validation and Development of a UAV-Based Model for Qatar’s Mega Sporting Events
Published 2023“…The key findings of the study are: (1) a valid and reliable UAV-based cybersecurity framework for FIFA mega sporting events was developed; (2) five critical factors were identified, including traceability, security and privacy, trust, acceptability, and preparedness; (3) all factors were significantly and positively correlated, highlighting the complexity of managing security systems in mega sporting events.…”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Integrated operational and financial approaches in supply chain risk management
Published 2012“…We develop a (base) stochastic optimization model that incorporates operational and financial features of the aforementioned supply chain. …”
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Green Supply Chains: A Comparative Efficiency Analysis in the Gulf and Beyond
Published 2023“…Strong contenders in green supply chains include the UAE, Oman, México, Panamá, and Ecuador.…”
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Interconnectedness between Supply Chain Resilience, Industry 4.0, and Investment
Published 2023“…These circumstances demand significant paradigm shifts, placing supply chain resilience (SCR) in the foreground of boardrooms and agendas of executive meetings. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…The expression of certain genes involved in proliferation and apoptosis was measured using reverse transcriptase‑polymerase chain reaction (RT‑PCR) and western blotting. To assess the effect of kefir on cancer metastasis, wound‑healing and time‑lapse movies, in addition to collagen‑based invasion assay, were used. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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Enhancing sustainability through resource efficiency in beef production systems using a sliding time window-based approach and frame scores
Published 2023“…<p dir="ltr">The food needs of the increasing global population, inefficiencies in supply chains, customer expectations and environmental concerns are the challenges to meeting resource-intensive protein needs sustainably. …”
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Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene
Published 2004“…The GG genotype was also significantly higher among patients (12.6%) than in controls (4.2%). χ2 analysis and family-based association studies were performed and suggested the association of CTLA4 exon 1 G polymorphism with T1D (p = 0.0229). …”
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Supply chain planning of vaccine and pharmaceutical clusters under uncertainty: The case of COVID-19
Published 2023“…This study aims to provide a mathematical model to support pharmaceutical supply chain planning during the COVID-19 epidemic. Additionally, it aims to offer new insights into hospital supply chain problems by unifying cold and non-cold chains and considering a wide range of pharmaceuticals and vaccines. …”
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Light chain amyloidosis presenting with autoimmune hepatitis-primary sclerosing cholangitis overlap syndrome
Published 2020“…<h3>Introduction</h3><p dir="ltr">Light chain (AL) amyloidosis is known to affect multiple organ systems. …”
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