Genetic distribution of natural killer receptors (killer immunoglobulin-like receptors) in familial mediterranean fever, recurrent tonsillitis and lymphoma in lebanese patients. (c... by Sabbagh, Amira Samir

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The combinatory effects of diet and exercise on BDNF gene expression by Bassil, Maya

“…The present results enrich our understanding of how exercise and different diets coordinate to induce BDNF gene expression and may be used in identifying novel therapeutic targets for depression…”
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Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk by Merhi, Mahmoud

“…Moreover, a significant smoking-gene interaction is determined with CYP1A1 MspI polymorphism rs4646903 and is associated with a decreased risk of CAD in current smokers (OR 0.52137). …”
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Mirizzi Syndrome: Mastering the Challenge, Characterization and Management Outcomes in a Retrospective Study of 60 Cases by Yousef Yahia (19756989)

“…Liver enzyme and bilirubin levels were significantly higher in the advanced types. Preoperative diagnosis was achieved in 70% of patients, with MRCP and ERCP being the most effective diagnostic tools. …”

Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B by Sadaf, Riaz

“…H9c2 cardiomyoblasts were stimulated with Angiotensin (Ang) II in the presence and absence of N-[2-methyl-4,5-bis(methylsulphonyl)-benzoyl]-guanidine, hydrochloride (EMD, EMD 87580), an NHE1 inhibitor or CA-074Me, a Cat B inhibitor, and various cardiac hypertrophic parameters, namely cell surface area, protein content and atrial natriuretic peptide (ANP) mRNA were analyzed. EMD significantly suppressed markers of cardiomyocyte hypertrophy and inhibited Ang II stimulated Cat B protein and gene expression. …”
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Role of microRNA 690 in Mediating Angiotensin II Effects on Inflammation and Endoplasmic Reticulum Stress by Kalhara R. Menikdiwela (18566698)

A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction by Gillian Douglas (7759118)

“…<h3>Aims</h3><p dir="ltr">Genome-wide association studies (GWAS) have consistently identified an association between coronary artery disease (CAD) and a locus on chromosome 10 containing a single gene, JCAD (formerly KIAA1462). However, little is known about the mechanism by which JCAD could influence the development of atherosclerosis.…”

Thermal challenges in lithium-ion battery technology: Investigating performance and thermal stability by Kenza Maher (22803425)

“…However, ensuring the safety and reliability of these batteries in desert environments presents significant challenges due to high temperatures, pervasive dust, and limited cooling mechanisms. …”

The multiomics analyses of cancer stem cells isolated from solid tumors can provide insight for their immunological characterization. by Neha Gopinath (15431052)

Addressing Challenges of Distance Learning in the Pandemic with Edge Intelligence Enabled Multicast and Caching Solution by Kashif Bilal (16896357)

Anti-hypertrophic effect of Na⁺/H⁺ exchanger-1 inhibition is mediated by reduced cathepsin B by Sadaf Riaz (6016985)

“…H9c2 cardiomyoblasts were stimulated with Angiotensin (Ang) II in the presence and absence of N-[2-methyl-4,5-bis(methylsulphonyl)-benzoyl]-guanidine, hydrochloride (EMD, EMD 87580), an NHE1 inhibitor or CA-074Me, a Cat B inhibitor, and various cardiac hypertrophic parameters, namely cell surface area, protein content and atrial natriuretic peptide (ANP) mRNA were analyzed. EMD significantly suppressed markers of cardiomyocyte hypertrophy and inhibited Ang II stimulated Cat B protein and gene expression. …”

The protective effects of conditioned media from human mesenchymal stem cells against Methylglyoxal-mediated injury of cultured endothelial cells by Maram Hasan (6672440)

“…Our findings showed a significant protective effect of MSCs-CM (50%) on MGO-mediated cell death and caspases 3/7 activation in endothelial cells.…”

G9a-mediated repression of CDH10 in hypoxia enhances breast tumour cell motility and associates with poor survival outcome by Francesco Casciello (18557613)

“…CDH10 overexpression significantly reduces cellular movements in breast cancer cell lines and prevents the hypoxia-mediated increase in cell motility. …”

Novel role of BRCA1 interacting C‐terminal helicase 1 (<i>BRIP1</i>) in breast tumour cell invasion by Balsam Rizeq (14779402)

“…Functional assays validated further the physiological relevance of <i>BRIP1</i> in tumour malignancy, and siRNA-mediated <i>BRIP1</i> knockdown significantly reduced BC cell motility by targeting key motility-associated genes. …”

Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mi... by Bogachev, Oleg

“…Furthermore, transplantation of AEBP1TG BM cells with the normal apolipoprotein E (ApoE) gene into ApoE⁻′⁻ mice (ApoE⁻′⁻/TG-BM chimera) leads to significant development of atherosclerosis (males: 2.5-fold, P = 0.0001 (en face), 4.7-fold, P = 0.0001 [aortic roots]; females: 1.8-fold, P = 0.0001 (en face), 3.0-fold, P = 0.0001 [aortic roots]) despite the restoration of ApoE expression. …”
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Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation by Mona Elsafadi (18614905)

“…Global transcriptome analysis revealed significant downregulation of several TGFβ responsive genes, namely, TAGLN, TMP1, ACTA2, TGFβ2, SMAD6, SMAD9, BMP2, and BMP4 in hBMSC^−Bone cells and upregulation on SERPINB2 and NOG. …”

Cathelicidin LL-37-induced transcriptome of human keratinocyte identifies chemokine CXCL10 link to T cell-mediated rosacea pathogenesis via JAK-1/STAT-1 pathway by Abdul W. Ansari (14557391)

“…Gene ontogeny (GO) enrichment of biological processes revealed activation of cellular response to molecules of bacterial origin, response to chemokines, and cytokine mediated signaling pathways. …”

Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv... by Abdoulaye Diane (14152749)

“…Interestingly, addition of Exendin-4 (50 nM) during the last 3 days of the differentiation significantly enhanced GSIS associated with increased expression of glucose-sensing apparatus genes (Glut2, G6P2C, GCK) and genes encoding mitochondrial oxidative phosphorylation machinery.…”

DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression by Mohamed Abu-Farha (25322)

<i>Haematococcus pluvialis</i> Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells by Nouralhuda Alateyah (21363215)

“…Interestingly, apoptosis was mediated by a significant loss of mutant p53 protein, and increased Bax/Bcl2 ratio. …”