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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Significance of Avicennia Marina in the Arabian Gulf Environment: A Review
Published 2025“…However, in the past two decades Gulf mangroves have been facing significant threats, including extensive coastal development, shoreline modification by establishing marinas and ports, and climate change-associated impacts such as sea-level rise and altered precipitation patterns, which pose significant risks to this fragile ecosystem. …”
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Challenges and practices identification in complex outsourcing relationships: A systematic literature review
Published 2022“…However, by virtue of its complexity, the complex outsourcing typically necessitates the interactions among various stakeholders from diverse regions and cultures, making it significantly more challenging to manage than traditional outsourcing. …”
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The Role of Project Management Soft Skills in Increasing Project Success
Published 2017“…As the world economy shifts towards an increasingly globalised market, the degree of competition becomes a more significant challenge which organisations face. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Challenges of morbid obesity in gynecological practice
Published 2023“…Surgery in the patient with morbid obesity is associated with several logistical challenges as well as increased surgical and peri-operative risks and increased cost.…”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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The Challenges of Corporate Governance Systems for Construction Project Management
Published 2014“…However, despite the growth in the area, the industry continues to face different challenges. Researchers have associated the challenges with poor corporate governance. …”
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Analysing the State of Inclusive Education in China: Challenges and Perspectives
Published 2025“…However, challenges remain in implementing inclusive practices and delivering quality education to children with special needs. …”
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An investigation into the impact of COVID-19 on school leadership in Dubai
Published 2022“…In an attempt to gain an insight into their experiences, the aim of this small-scale research project was to explore the challenges that principals have encountered during the COVID-19 pandemic and the solutions they made to overcome these challenges. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Sustainability Assessment Indicators in Higher Education: Stakeholders' Perception and Challenges
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Feeder protection challenges with high penetration of inverter based distributed generation
Published 2013“…The paper discusses the challenges for the protection system related to the integration of increasingly significant amounts of DG and highlights the need for more sophisticated protection systems.…”
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