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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Analysing the State of Inclusive Education in China: Challenges and Perspectives
Published 2025“…The global focus on inclusive education has intensified, with countries working to ensure equal school access for all, including those with disabilities. China has made significant legislative advancements to support inclusive education in line with international standards. …”
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The Challenges of Corporate Governance Systems for Construction Project Management
Published 2014“…However, despite the growth in the area, the industry continues to face different challenges. Researchers have associated the challenges with poor corporate governance. …”
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Editorial: At the Crossroads: Lessons and Challenges in Computational Social Science
Published 2016“…At the turn of the century, however, it was clear that huge challenges—and new opportunities— lied ahead: the digital communication technologies, and their associated data deluge, began to nurture those models with empirical significance. …”
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An investigation into the impact of COVID-19 on school leadership in Dubai
Published 2022“…In an attempt to gain an insight into their experiences, the aim of this small-scale research project was to explore the challenges that principals have encountered during the COVID-19 pandemic and the solutions they made to overcome these challenges. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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Impact of AI and Dynamic Ensemble Techniques in Enhancing Healthcare Services: Opportunities and Ethical Challenges
Published 2024“…Our findings suggest that while significant progress has been made, multidisciplinary collaboration and continued innovation are crucial for overcoming current limitations and realizing the full potential of AI in healthcare.…”
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Two decades of hydrogen-powered ships (2000–2024): Evolution, challenges, and future perspectives
Published 2025“…Over the past two decades, significant strides have been made in hydrogen energy conversion, storage, and bunkering technologies, which have been implemented and tested across various vessels, leading to the growth of a global fleet of hydrogen-powered vessels. …”
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Gifted Education Perceptions and Implementation of a Key Leader in a K-12 Private School in Dubai
Published 2024“…The UAE has made significant strides in inclusive education, with gifted education gaining attention as part of the broader agenda for educational excellence. …”
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Towards secure and trusted AI in healthcare: A systematic review of emerging innovations and ethical challenges
Published 2025“…</p><h3>Results</h3><p dir="ltr">The analysis brought out both the innovative technologies and the continued challenges. Explainable AI (XAI) emerged as one of the significant developments. …”
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Perceptions and Views Regarding the Role of the Special Educational Needs and Disabilities Coordinators (SENDCos) and Challenges Affecting the Role in the United Arab of Emirates (...
Published 2017“…However, like many other countries, the UAE faces many significant social, cultural and financial challenges in the field of special education that would affect this role. …”
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Investigating Gender-Related Workplace Challenges in Lebanese Private Universities: A focus on HR Policies and Career Advancement for Non-Academic Working Mothers
Published 2024“…While significant progress has been made in achieving gender equality in the workplace, women continue to encounter persistent challenges that impede their professional advancement. …”
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E-learning in Saudi Arabia: Past, present and future
Published 2014“…The new learning trend has made it mandatory to equip teachers in educational institutions with the necessary skills to cope with the new challenges. …”
