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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
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The Grid Iron Patterns & Detached Villas as the Main Drivers of Sharjah City’s Urban Sprawl
Published 2021“…On the other hand, the same study proved that the grid system and the villa model are the main reason behind the urban sprawl of the city. …”
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Editorial: At the Crossroads: Lessons and Challenges in Computational Social Science
Published 2016“…At the turn of the century, however, it was clear that huge challenges—and new opportunities— lied ahead: the digital communication technologies, and their associated data deluge, began to nurture those models with empirical significance. …”
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QFD-based optimization model for mitigating sustainable supply chain management adoption challenges for Bangladeshi RMG industries
Published 2024“…The implications extend beyond the RMG sector, offering a replicable model for other industries and regions facing similar sustainability challenges.…”
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Implementing a collaborative care model for child and adolescent mental health in Qatar: Addressing workforce and access challenges
Published 2024“…This commentary explores the model’s feasibility, addressing challenges like workforce shortages and psychotropic prescribing processes. …”
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Survey of Multimodal Federated Learning: Exploring Data Integration, Challenges, and Future Directions
Published 2025“…Traditional machine learning (ML) models rely on centralized architectures, which, while powerful, often present significant privacy risks due to the centralization of sensitive data. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Impact of AI and Dynamic Ensemble Techniques in Enhancing Healthcare Services: Opportunities and Ethical Challenges
Published 2024“…Dynamic ensemble techniques, which leverage multiple predictive models to improve outcome accuracy, offer significant promise in addressing the complexities of patient data and disease manifestations. …”
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Deep random vector functional link transformer network with multiple output layers for significant wave height forecasting
Published 2025“…<p>Accurate control of wave energy devices relies heavily on precise forecasts of wave heights, yet the dynamic and fluctuating nature of historical wave data presents significant challenges to achieving this precision. …”
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Power System Stability With High Penetration of Renewable Energy Sources: Challenges, Assessment, and Mitigation Strategies
Published 2025“…<p dir="ltr">The incorporation of renewable energy sources (RESs) into power systems has significantly increased in recent years due to growing environmental, economic, and energy security concerns, posing new challenges for power system stability. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
Published 2008“…Upon rechallenge, in the animal group that had received WP1066 via o.g., the median survival was 18 days (95% CI: 17, NA), which was significantly different compared to naïve animals challenged at the same time that had a median survival of 11 days (95% CI; 10, NA) (p<0.001); however, there were only 10% long-term survivors suggesting that treatment alone did not generate significant long-term protective immunity. …”
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Deep Learning in LncRNAome: Contribution, Challenges, and Perspectives
Published 2020“…We also outlined DL-based techniques leveraged in lncRNAome, highlighting the challenges computational scientists face while developing DL-based models for lncRNAome. …”
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Intensive English Students Communication Skills: Challenges and Solutions
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