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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Grid Iron Patterns & Detached Villas as the Main Drivers of Sharjah City’s Urban Sprawl
Published 2021“…On the other hand, the same study proved that the grid system and the villa model are the main reason behind the urban sprawl of the city. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Effect of Pilot-Points Location on Model Calibration: Application to the Northern Karst Aquifer of Qatar
Published 2019“…The pilot-points method produces smoothly distributed parameters compared to the zonation approach; however, the number and placement of pilot-points can be challenging. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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Computation of the 1‐dB compression point in radio frequency amplifier circuits using moments analysis
Published 2015“…Nonlinear distortion analysis is one of the most computationally challenging aspects in the simulation of radio frequency circuits. …”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
Published 2006Get full text
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Challenges facing teacher education in Qatar: Q methodology research
Published 2022“…Based on the results of this study, we argue that these consensus points represent the main challenges facing teacher education in Qatar.…”
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Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance
Published 2025“…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…”
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Gifted Education Perceptions and Implementation of a Key Leader in a K-12 Private School in Dubai
Published 2024“…The UAE has made significant strides in inclusive education, with gifted education gaining attention as part of the broader agenda for educational excellence. …”
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The FASILA Score: A Novel Bio-Clinical Score to Predict Massive Blood Transfusion in Patients with Abdominal Trauma
Published 2019“…<h2>Background</h2> <p>Early identification of patients who may need massive blood transfusion remains a major challenge in trauma care. This study proposed a novel and easy-to-calculate prediction score using clinical and point of care laboratory findings in patients with abdominal trauma (AT).…”
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A New Restriction Endonuclease-Based Method for Highly-Specific Detection of DNA Targets from Methicillin-Resistant Staphylococcus aureus
Published 2014“…Sequences of target oligonucleotides were altered to demonstrate that (i) any mutation of the restriction site reduced the signal to zero; (ii) double and triple point mutations of sequences flanking the restriction site reduced restriction to 50–80% of the positive control; and (iii) a minimum of a 16-bp target-probe dsDNA hybrid was required for significant cleavage. …”
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A High‐Performance MPPT Solution for Solar DC Microgrids: Leveraging the Hippopotamus Algorithm for Greater Efficiency and Stability
Published 2025“…<p dir="ltr">The rapid growth of modern civilization has led to increased global warming and climate challenges. Variations in atmospheric temperature, sunlight intensity and other factors significantly impact the performance of photovoltaic (PV) systems. …”
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YOLO-DefXpert: An Advanced Defect Detection on PCB Surfaces Using Improved YOLOv11 Algorithm
Published 2025“…Accurately identifying small defects on PCB surfaces remains a considerable challenge, particularly under complex background conditions, due to the intricate and compact layout of the boards. …”