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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Challenges facing teacher education in Qatar: Q methodology research
Published 2022“…<p dir="ltr">This study aims to identify the challenges facing teacher education in Qatar. Through Q methodology, it examines the ways in which schoolteachers, preservice teachers, teacher education faculty, and Ministry of Education and Higher Education personnel identify what they see as significant challenges faced by teacher education in the country. …”
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Opportunities and Challenges of Hydrogen Ports: An Empirical Study in Australia and Japan
Published 2024“…The findings reveal that there are significant opportunities for both countries’ H<sub>2</sub> ports and their respective regions, which encompass business transition processes and decarbonisation. …”
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The rise of Qatar as a soft power and the challenges. (c2017)
Published 2017“…The analysis focused on identifying the continuous stream of evidence on the process through which the country has acquired soft power, and the challenges in the process. …”
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Industrial Processes Performance Improvement using Six Sigma Principles and Tools
Published 2019“…In this project, TQM and Six Sigma DMAIC methodology were used to improve the process of paper bag making to make sure that the output of the manufacturing process meets the demands of customers. …”
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Sustainability Assessment Indicators in Higher Education: Stakeholders' Perception and Challenges
Published 2024Get full text
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A Decade of Open Access Funding in Qatar: from challenges to opportunities
Published 2025“…It will cover the transition from ad-hoc requests to the establishment of a team of administrators to manage the fund, the setup of the QNL consortium, negotiations related to the first open access agreements, and the difficulties in reaching equitable agreements with publishers, as well as establishing meaningful workflows. The most significant challenge has been securing sustainable funding. …”
