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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Mapping subnational HIV mortality in six Latin American countries with incomplete vital registration systems
Published 2021“…</p><h3>Results</h3><p dir="ltr">All countries displayed over a 40-fold difference in HIV mortality between municipalities with the highest and lowest age-standardized HIV mortality rate in the last year of study for men, and over a 20-fold difference for women. Despite decreases in national HIV mortality in all countries—apart from Ecuador—across the period of study, we found broad variation in relative changes in HIV mortality at the municipality level and increasing relative inequality over time in all countries. …”
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
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Hedonic valuation of land protection methods: implications for cluster development.
Published 2014“…The key findings of the study are: (i) proximity to national or state park land and to city or county open space has a significant positive impact on property values, while proximity to national forest land or to privately conserved land exhibits no significant effects; and, (ii) inclusion of a property within a cluster development decreases its value by 17 to 26 %. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …”
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Challenges in child and adolescent health across the Arab Gulf countries—Focus on metabolic health
Published 2025“…Children and adolescents lack access to specialised professionals for disease management across all healthcare services in the region, with a lack of multidisciplinary teams and support groups. …”
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A comparison of the influence of personal and cultural values on the consumption of luxury goods across Arab regions
Published 2016“…Beliefs such as the assumption that group orientation plays a significant role in consumers' decision making and that hedonism is not appreciated in Arab cultures are challenged, which indicate slow changes in the Arab cultures. …”
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Small molecule inhibition of stat3 enhances survival in mice with intracerebral melanoma
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An examination of how climate change could affect the future spread of Fusarium spp. around the world, using correlative models to model the changes
Published 2023“…Climate change is predicted to have a significant impact on the geographic distribution of various flora, fauna, and insect species by expanding, contracting, or shifting their suitable climate environment. …”
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Finance–growth nexus in a changing political region
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An examination of how climate change could affect the future spread of <i>Fusarium</i> spp. around the world, using correlative models to model the changes
Published 2023“…<p dir="ltr"><u>Climate change</u> is predicted to have a significant impact on the geographic distribution of various flora, fauna, and insect species by expanding, contracting, or shifting their suitable climate environment. …”
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Suppression of Unstable Flow by Using Rough Surfaces at Small Mass Flow Rates in a Radial Diffuser
Published 2006Get full text
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Conceptual Skills in Leading Change: A Competence Approach to Public Sector Leadership
Published 2019“…Leaders’ capacity to think about abstract and complex ideas has long been acknowledged as essential to leadership tasks such as planning and analysis; however, because conceptualisation is often ambiguous and difficult to understand, many frameworks of leadership and change lack clarity on the actual significance of leaders’ conceptual skills when leading change. …”
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