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Inotodiol decreases clone formation in HCC cells.
Published 2025“…In addition, inotodiol showed to induce apoptosis, characterized by an increase in Bax expression, a decrease in Bcl-2, Bcl-XL and MCL1 expression, the initiation of cleaved PARP1 and cleaved caspase 3, and inhibition of the MAPK/ERK pathway. …”
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ATGL-1 levels increase and lipid droplets decrease in response to <i>N. parisii</i> infection.
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Increased or reduced ATGL-1 activity does not significantly change <i>N. parisii</i> growth.
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IRE1 depletion decreases heterochromatin, DNA and H3K9me3 methylation, and UHRF1.
Published 2025Subjects: “…transcription factor xbp1s…”
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Table 1_Decreased neuronal excitability in hypertriglyceridemia hamsters with acute seizures.docx
Published 2024“…</p>Conclusion<p>Hypertriglyceridemic Apoc2<sup>−/−</sup> hamsters exhibited reduced seizure frequency and decreased cortical neuron excitability. The upregulation of ZDHHC14, leading to increased I<sub>A</sub>, may be a crucial mechanism underlying the observed seizure protection.…”