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Detection of statistically significant network changes in complex biological networks
Published 2017“…<h3>Background</h3><p dir="ltr">Biological networks contribute effectively to unveil the complex structure of molecular interactions and to discover driver genes especially in cancer context. It can happen that due to gene mutations, as for example when cancer progresses, the gene expression network undergoes some amount of localized re-wiring. …”
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Investigating energy savings due to implementing green roof on existing residential buildings in UAE
Published 2013“…In recent years, building energy consumption keeps rising due to growth in population, increasing demand for comfort in indoor environment and global climate changing. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…<p dir="ltr">NanoLuc (NLuc) <u>luciferase</u> has found extensive application in designing a range of <u>biologica</u><u>l</u><u> assays,</u> including <u>gene expression analysis</u>, protein-protein interaction, and protein conformational changes due to its enhanced brightness and small size. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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The Global Economic crisis & organisation change: case studies in the UAE
Published 2009“…Much of the restructuring took place under the banner of increasing corporate financial performance, but a significant byproduct of the deep-rooted organisational change it involves is additional strain on the organisation’s relationship with employees, communities, taxpayers, governments & stakeholders (Heugens, P., Schenk, H. 2004). …”
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Essays on the effect of excess compensation and governance changes on firm value
Published 2012“…Our results suggest that an increase in director excess compensation decreases the likelihood of CEO turnover, reduces the turnover-performance sensitivity, and increases managerial entrenchment. …”
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Climatic change impacts on the energy requirements for the built environment sector
Published 2023“…Furthermore, the heating load may be lowered due to the higher winter temperatures; however, the cooling load will be significantly augmented for some regions. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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11p15 DNA-methylation analysis in monozygotic twins with discordant intrauterine development due to severe twin-to-twin transfusion syndrome
Published 2013“…Recent studies indicate a plasticity of the 11p15 epigenotype in response to environmental changes during early stages of human development. …”
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Conceptual Skills in Leading Change: A Competence Approach to Public Sector Leadership
Published 2019“…The highest level of leaders makes fewer conceptual errors, and these errors increase as the levels decrease. Furthermore, just as there are essential conceptual skills to lead change, there are also misconceptions. …”
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Managing change process: A case study of a private school in Sharjah
Published 2016“…The significance of change process management increases as the modern world trends of education and learning require a change. …”
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