A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…<p dir="ltr">NanoLuc (NLuc) <u>luciferase</u> has found extensive application in designing a range of <u>biologica</u><u>l</u><u> assays,</u> including <u>gene expression analysis</u>, protein-protein interaction, and protein conformational changes due to its enhanced brightness and small size. …”

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells by Nihal AlMuraikhi (6002234)

“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”

Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion by Khoury, Nathalie

“…The expression of certain genes involved in proliferation and apoptosis was measured using reverse transcriptase‑polymerase chain reaction (RT‑PCR) and western blotting. …”
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Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk by Merhi, Mahmoud

“…Moreover, a significant smoking-gene interaction is determined with CYP1A1 MspI polymorphism rs4646903 and is associated with a decreased risk of CAD in current smokers (OR 0.52137). …”
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Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications by Jingxuan Shan (4711089)

“…We found a highly significant association between the <b><i>CCND1</i></b><b> </b><b>rs614367-TT</b> genotype (OR = 5.14; <i>P</i> = 0.004) and TNBC risk, and identified a significant association between the <b>rs614367-T</b> allele and decreased PFS in TNBC. …”

Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients by Esraa K. Al-Amleh (16023071)

“…Platelet counts, on the other hand, dramatically decreased in both IM and (HU + IM).</p><h3>Conclusion</h3><p dir="ltr">Because the studied genes (BCL2, PP2A, CIP2A, and WT1) are participating in cell proliferation and death, the findings show that the examined genes are significant to understand the efficacy of various therapies. …”

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes by Maryam Aghadi (17128819)

“…Lack of FOXA2 resulted in significant alterations in the expression of key developmental and functional genes in hepatic progenitors (HP) and mature hepatocytes (MH) as well as an increase in the expression of ER stress markers. …”

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 by Olfa Khalifa (10914452)

“…</p> <p>Results: Treatment with 200nM Ex-4 for 3h decreased the OA-induced lipid buildup significantly (p<0.05). …”

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss by Meritxell Espino Guarch (18810097)

Segmenting the Travel Market Based on the Tourists' Need for Novelty by Assaker, Guy

“…Using cluster, chi-square, and analysis of variance, the results indicated that travelers can be grouped into three segments based on novelty-seeking behavior. …”
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Segmenting meeting and event management organizations based on business performance by Assaker, Guy

“…Using data collected from 120 MEMOs in Australia, cluster analysis, chi-square, and Kruskal–Wallis were used to categorize and profile these organizations based on their performance levels. …”
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Type 2 Diabetes Mellitus Automated Risk Detection Based on UAE National Health Survey Data: A Framework for the Construction and Optimization of Binary Classification Machine Learn... by Mohamed, AlShuweihi

“…This research motivated by the unprecedented increase in diabetes and specifically Type 2 Diabetes Miletus (T2DM), proposes two significant contributions. The first is a comprehensive ML framework for the construction of diagnostic binary classification high accuracy models to predict T2DM in the United Arab Emirates based on STEPS style National Health Survey. …”
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Population based treatment strategy of H pylori in Qatar: Through clinical and demographic insights by Zohaib A.W. Khan (22051949)

“…Pylori directed therapies were documented and compared. Pearson’s Chi-square test, independent samples ttest or analysis of variance (ANOVA) was used as appropriate to compare various parameters between patients. …”

Clinical and radiographic outcome of a bioceramic sealer compared to a resin-based sealer: a retrospective study by Hamzah Ahmad Bani-Younes (22303513)

“…Clinical outcome of the RCTs using both types of sealers were measured by percentages of success rates. Chi square statistical test was used to analyze data at 0.01 and level of significance via SPSS software. …”

The Relationship Between the Learning Styles of Students in Grades Five and Six and Their Held Misconceptions About Dividing Fractions Based on Kolb’s Model by Abosalem, Yousef Mahmoud

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Potentially inappropriate medications use in community-based aged patients: a cross-sectional study using 2012 Beers criteria by Kuyumjian, Yara-Mary

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Enhanced event-based surveillance: Epidemic Intelligence from Open Sources (EIOS) during FIFA World Cup 2022 Qatar by Mohamed, Sallam

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Alpelisib Therapy in 2 Patients With Congenital Hyperinsulinism by Khalid Alburshad (22467244)

“…This allowed for the tapering and discontinuation of other medications (diazoxide and octreotide) and facilitated a transition to bolus gastrostomy-tube/oral feeding. No significant adverse effects were reported. Alpelisib shows promise as both an adjunctive and primary therapy for CHI, improving glucose levels and reducing dependence on continuous feeding and other medications. …”

BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells by Ali Alhoshani (3720718)

“…This effect was associated with a significant increase in the percentage of apoptotic MDA-MB-231 cells and in the expression of the apoptotic genes, caspase 3, caspase 7, and BAX, with inhibition of antiapoptotic gene, BCL-2 levels. …”

Aqueous urtica dioica leaves extract inhibits proliferation of acute myeloid leukemia cells in vitro by Rizk, Sandra

“…The decrease was more significant after 72hr with an IC50 at 16mg/ml. …”
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