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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Genetic Basis and Prognostic Value of Exercise QT Dynamics
Published 2020“…Increased QT dynamics during recovery was significantly associated with all-cause mortality in the univariate Cox regression analysis (hazard ratio, 1.09 [95% CI, 1.05–1.13], P =2.28×10 -5 ), but the association was not significant after adjusting for clinical risk factors.…”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …”
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
Published 2014“…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …”
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The potential impact and diagnostic value of inflammatory markers on diabetic foot progression in type II diabetes mellitus: A case–control study
Published 2024“…</p><h3>Results </h3><p dir="ltr">CRP, IL-6, and FBS were found to be significant predictors of diabetic foot (OR=1.717, 95% CI=1.250–2.358, <i>P</i> =0.001; OR=1.434, 95% CI=1.142–1.802, <i>P</i> =0.002; and OR=1.040, 95% CI=1.002–1.080, <i>P</i> =0.037), respectively. …”
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Modeling of photovoltaic soiling loss as a function of environmental variables
Published 2017“…The ANN model performed significantly better in predicting daily ΔCIas well as cumulative CI than the linear model in term of R2 values and statistical error indexes. …”
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Closed-loop vasopressor systems for hemodynamic stability during cesarean delivery and maternal and neonatal outcomes: a systematic review and meta-analysis
Published 2025“…In three RCTs (n = 654), wobble (MD −0.66 %; 95 % CI −1.29 to −0.02; <i>P</i> = 0.04), hypotension incidence (RR 0.67; 95 % CI 0.55 to 0.82; <i>P</i> < 0.01), and the highest and lowest systolic blood pressures values (MD −4.05 mmHg; 95 % CI −7.03 to −1.06; <i>P</i> < 0.01 and MD 5.39 mmHg; 95 % CI 2.17 to 8.60; <i>P</i> < 0.01, respectively) were minimized with closed-loop vasopressor systems, but no significant differences were observed in other primary outcomes. …”
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002)
Published 2002“…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …”
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Effect of Hydroxycut Intake on Fasted and Postprandial Lipemia in Rats
Published 2015“…A significant increase in serum blood glucose level was observed with hydroxycut intake in the presence of a high-fat diet. …”
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Effect of partial medial meniscectomy on anterior tibial translation in stable knees
Published 2013“…Results There is a significant difference between pre and post-operative KT MM mean values for the operated knees (CI: -3.933953 to −2.947297, p < 0.0001). …”
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The chemotherapeutic effect of β-2-himachalen-6-ol in chemically induced skin tumorigenesis
Published 2018“…Only Cisplatin treatment caused a significant decrease in body weight and increase in serum ALT. …”
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Effect of Crude Oil Products on the Geotechnical Properties of Sandy Soil
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doctoralThesis