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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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Predicting stability of classes in an object-oriented system
Published 2010“…However, in almost all cases, these models were not efficient when used to predict the quality characteristics (stability or other) of new unseen software as their prediction accuracy decreases significantly. In this paper, we present a heuristic approach that relies on the adaptation and recombination of already built predictive models to new unseen software.The predictive models are all rule-based models and the approach is tested on the stability of classes in an object-oriented software system. …”
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Orthodontic camouflage versus orthodontic-orthognathic surgical treatment in borderline class III malocclusion: a systematic review
Published 2022“…Regarding the vertical jaw relation, one study reported a significant decrease in mandibular plane inclination in OC and a significant increase in OOS. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
Published 2023“…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …”
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
Published 2014“…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…”
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Mixed precision iterative refinement with adaptive precision sparse approximate inverse preconditioning
Published 2025“…<p dir="ltr">Hardware trends have motivated the development of mixed precision algorithms in numerical linear algebra, which aim to decrease runtime while maintaining acceptable accuracy. …”
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The Relationship between Using of an Intelligent Tutoring System and Class Achievement in a Basic Mathematics Course.
Published 2008“…The experimental results failed to show any significant positive effect.…”
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TEACHING STRATEGIES USED IN INCLUSION SCIENCE CLASSES TO DEVELOP SCIENCE LEARNING OF STUDENTS WITH LEARNING DIFFICULTIES IN PRIVATE SCHOOLS IN DUBAI
Published 2023“…The researcher then held a semi-structured interview with 14 science teachers individually to gain a deeper understanding of their point of view regarding the teaching strategies used in their classes. Except for a few highlighted points, the data collected and independent t-test results show that there are no significant differences in using one strategy over another in science classes. …”
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Evaluation of oral reading fluency outcomes using the whole-class choral reading strategy and the repeated reading strategy. (c2017)
Published 2017“…The results show that the students who receive the Repeated Reading strategy scored better than those receiving the Whole Class Choral Reading strategy. Based on these results, a new oral reading fluency strategy was created: “The Repeated Choral Reading Strategy" which was tested on another set of students and showed significant improvement in students' oral reading fluency. …”
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The Stakeholders’ Perceptions about the Effectiveness of iPads Integrations in Third Grade English Classes in a Private School in Sharjah, UAE
Published 2023“…The presence of mobile technologies within elementary classrooms has been increasing yet review studies which measure the effectiveness of mobile technologies to support children’s learning in English classes remains scarce. The purpose of this study is to examine the attitude of parents, teachers, and leaders of the iPad’s integrations in third grade English classes in one of the private schools in Sharjah. …”
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Serum 25-hydroxyvitamin D concentrations are inversely associated with body adiposity measurements but the association with bone mass is non-linear in postmenopausal women
Published 2021“…In multivariable adjusted analysis, no association was found between serum 25(OH)D concentration and bone mass when serum 25(OH)D was categorized. In a continuous variable analysis, the association between 25(OH)D and bone mass was significant, non-linear, inverse ‘U’. …”
