DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer by Varun Sasidharan Nair (5396393)

DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer by Varun Sasidharan Nair (5396393)

“…</p><h3>Results</h3><p dir="ltr">We first assessed the expression level of six immune checkpoints/ligands and found that PD-1, CTLA-4, TIM-3, and LAG-3 were significantly upregulated in breast tumor tissues (TT), compared with breast normal tissues (NT). …”

Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through... by Masri, Oussama Samer

“…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …”
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A population study of clinically actionable genetic variation affecting drug response from the Middle East by Puthen Veettil Jithesh (12040358)

“…<p dir="ltr">Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. …”

Development of mental health services for lower-skilled migrant workers in Qatar by Javed Latoo (14777125)

Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid by Keita Kakuda (9668898)

“…However, conventional shaking-based assays are time-consuming procedures, and the clinical significance of the diversity of seeding activity among patients remains to be clarified. …”

Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients by Salman M. Toor (8854751)

Circulating and Tumor-Infiltrating Immune Checkpoint-Expressing CD8+ Treg/T Cell Subsets and Their Associations with Disease-Free Survival in Colorectal Cancer Patients by Alhasan Alsalman (14802873)

Role of Epigenetic Modifications in Inhibitory Immune Checkpoints in Cancer Development and Progression by Reem Saleh (3513056)

“…These epigenetic aberrations can significantly contribute to the transcriptomic upregulation of ICs and their ligands. …”

Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits by Shaza B. Zaghlool (10836602)

“…We identify 98 CpG-protein associations (pQTMs) at a stringent Bonferroni level of significance. Overlapping associations with transcriptomics, metabolomics, and clinical endpoints suggest implication of processes related to chronic low-grade inflammation, including a network involving methylation of <i>NLRC5</i>, a regulator of the inflammasome, and associated pQTMs implicating key proteins of the immune system, such as CD48, CD163, CXCL10, CXCL11, LAG3, FCGR3B, and B2M. …”

Hyper-Hypo study: A Retrospective Observational Study of Neonatal Hypoglycemia Related to Maternal Hypertension by Thiruveni Ramkumar (17075051)

“…On the other hand, neonates of hypertensive mothers administered with methyldopa showed a significant decrease of initial blood glucose reading.…”

Entrustable professional activities by Youssef, Nazih

“…Despite their intuitive match with decisions made in the clinical environment daily by clinicians, the development of specialty-specific EPAs and corresponding culturally situated assessment tools has lagged. …”
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Rescue cerclage by Khoury, Alfred

“…Advanced dilation of 3 cm and/or prolapsed membranes (n = 18) did not decrease the likelihood of reaching 28 weeks. Mean gestational age at delivery for this subset of patients was 30.7 ± 7.2 weeks. …”
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Food safety knowledge attitude and practices of oncology nurses, in Lebanese hospitals by Angy, Mallah

“…Knowledge scores were higher among nurses holding a graduate degree (mean = 85; p < 0.05), and those who attended a training course (mean = 79; p < 0.05). …”
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Sleeve Gastrectomy in Patients with Type 2 Diabetes: Anthropometric and Cardiometabolic Improvements at 1, 3, 5, 7, and 9 years—Are the Initial Benefits Sustained? by Wahiba Elhag (5245547)

“…Mean HbA1c significantly decreased from 8.1%preop to 6.77%_{year 9}. …”

Sex differences on quality of life and mental health outcomes when using a brief cognitive-behavioral skill building intervention with adolescent Syrian refugees: a secondary analy... by Kazandjian, Chant

“…Among males only, significant decreases in depression and anxiety scores were observed with significant improvement in total QOL.…”
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Food safety knowledge attitude and practices of oncology nurses, in Lebanese hospitals by Angy Mallah (17831954)

“…Knowledge scores were higher among nurses holding a graduate degree (mean = 85; p < 0.05), and those who attended a training course (mean = 79; p < 0.05). …”

Investigating the impact of remittance outflows and oil price on economic growth in Gulf Cooperation Council countries by Mouyad Alsamara (17823668)

“…These findings have significant implications for labor markets and nationalization policies in the GCC countries.…”

Investigating the impact of remittance outflows and oil price on economic growth in Gulf Cooperation Council countries by Mouyad, Alsamara

“…These findings have significant implications for labor markets and nationalization policies in the GCC countries.…”
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Oxygen targets following cardiac arrest: A meta-analysis of randomized controlled trials by Huzaifa Ahmad Cheema (16328980)

“…</p> <h3>Conclusions</h3> <p>Conservative oxygen therapy did not decrease mortality, improve neurologic recovery, or decrease ICU LOS as compared to a liberal oxygen regimen. …”