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Ultrasound triggered release of Trastuzumab-conjugated immunoliposomes targeting breast cancer
Published 2018Get full text
doctoralThesis -
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Ultrasound-responsive Nanocarriers in Cancer Treatment: a review
Published 2021Get full text
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Kinetics of acoustic release of doxorubicin from stabilized and unstabilized micelles and the effect of temperature
Published 2011“…Kinetic models were used to regress release and re-encapsulation time constants for three different compounds, namely non-stabilizedռ Pluronic® P105 micelles, P105 micelles stabilized using an interpenetrating network of N,N-diethylacrylamide and micelles formed by PEO-b-poly(NIPAAm-co-HEMA-lactate ռ). …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …”
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Functionalized Metal Organic Frameworks For Chemotherapy Drug Delivery
Published 2020Get full text
doctoralThesis -
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Self-reported awareness and attitude of cancer patients towards clinical nurse coordinators
Published 2017“…Methods: This is a cross sectional study that was conducted by distributing a self-reported and anonymous survey to 240 cancer patients visiting the center. …”
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Assessment of treatment burden and its impact on quality of life in dialysis-dependent and pre-dialysis chronic kidney disease patients
Published 2021“…<h3>Background</h3><p dir="ltr">The management of chronic kidney disease (CKD) and its complications places a significant burden on patients, resulting in impairment of their health-related quality of life (HR-QOL). …”
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
Published 2019“…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …”
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The Effect of Auditor Characteristics on the Quality of Segment Disclosures of Diversified Firms
Published 2024Get full text
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Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) and Ultrasound.
Published 2016Get full text
doctoralThesis -
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Applying value-based strategies to accelerate access to novel cancer medications: guidance from the Oncology Health Economics Expert Panel in Qatar (Q-OHEP)
Published 2023“…<h3>Background</h3><p dir="ltr">In line with global trends, cancer incidence and mortality may have decreased for specific types of cancer in Qatar. However, the cancer-related burden on patients, healthcare systems, and the economy is expected to expand; thus, cancer remains a significant public healthcare issue in Qatar. …”
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Non-diabetic ketoacidosis secondary to primary hyperthyroidism
Published 2022“…This was associated with decreased appetite and weight loss.</p><h3>Diagnosis</h3><p dir="ltr">Laboratory findings were significant for high anion gap metabolic acidosis, positive ketones in the urine, and high serum B-hydroxybutyrate. …”
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Light chain amyloidosis presenting with autoimmune hepatitis-primary sclerosing cholangitis overlap syndrome
Published 2020“…Her liver enzymes (Alkaline phosphatase, Alanine aminotransferase, Aspartate aminotransferase had decreased significantly.</p><h3>Conclusions</h3><p dir="ltr">AL amyloidosis can very rarely present as AIH-PSC overlap syndrome, manifesting with raised liver enzymes, biliary strictures, pruritis and positive liver antibodies. …”
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Diversity, Concentration and Dynamics of Culturable Fungal Bioaerosols at Doha, Qatar
Published 2020“…The count of <em>Alternaria</em> spp. and <em>Fusarium</em> spp. were significantly higher at the Industrial area site, which corresponds to a higher CO2 level than the Qatar University site. …”
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Modulation of SLFN11 induces changes in DNA Damage response in breast cancer
Published 2023“…The use of a CRISPR-dCas9 UNISAM and KRAB system could increase or decrease SLFN11 expression significantly (up to fivefold), stably and specifically in BT-549 and T47D cancer cell lines. …”