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Detection of statistically significant network changes in complex biological networks
Published 2017“…</p><h3>Methods</h3><p dir="ltr">In this paper, we propose an improvement over the state-of-the-art based on the Generalized Hamming Distance adopted for evaluating the topological difference between two networks and estimating its statistical significance. The proposed procedure exploits a more effective model selection criteria to generate <i>p</i>-values for statistical significance and is more efficient in terms of computational time and prediction accuracy than literature methods. …”
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Deep Models for Stroke Segmentation: Do Complex Architectures Always Perform Better?
Published 2024“…These findings suggest that proposed complex architectures may be task-specific and simpler models with appropriate pre-/post-processing pipeline can be equally or more effective in generalization across different tasks in medical image segmentation.…”
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Low-Complexity Machine Learning-based Behavioral Modeling of Power Amplifiers
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Novel platinum (II) and platinum (IV) complexes exhibit potent chemotherapeutic properties in breast and skin cancer models
Published 2022“…The lethal and most tolerated doses were measured for both complexes in mice. The chemotherapeutic potential was assessed in a DMBA-induced breast cancer model in rats as well as a DMBA/TPA-induced skin cancer model in mice. …”
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Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
Published 2018“…<h3>Background</h3><p dir="ltr">Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson’s disease (PD). Animal models of PD can serve as a platform to investigate the role of neuroinflammation in degeneration in PD. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Editorial: At the Crossroads: Lessons and Challenges in Computational Social Science
Published 2016“…At the turn of the century, however, it was clear that huge challenges—and new opportunities— lied ahead: the digital communication technologies, and their associated data deluge, began to nurture those models with empirical significance. Only a decade later, the advent of the Web 2.0, the Internet of Things and a general adoption of mobile technologies have convinced researchers that theories can be mapped to real scenarios and put into empirical test, closing in this way the experiment-theory cycle in the best tradition of physics</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Physics<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" rel="noreferrer noopener" target="_blank">https://creativecommons.org/licenses/by/4.0/</a> <br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fphy.2016.00037" target="_blank">https://dx.doi.org/10.3389/fphy.2016.00037</a></p>…”
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Correlation Clustering via s-Club Cluster Edge Deletion
Published 2023“…Cluster Editing, a known model for correlation clustering, has garnered significant consideration in the parameterized complexity area and has been utilized in a range of practical contexts. …”
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Habitat Complexity Influences the Microhabitat Choices of Desert Beetles
Published 2011“…We present a model for prey survivorship varying with average space size/prey width (Sp/Py) and total cover within an area (Ct/At), which are habitat complexity indices. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Deep random vector functional link transformer network with multiple output layers for significant wave height forecasting
Published 2025“…This paper introduces a novel random vector functional link transformer (RFT) and ensemble deep random vector functional link transformer (edRFT) networks to capture the dynamic characteristics of significant wave heights. The model employs hidden blocks based on transformer encoders to effectively capture complex sequential dependencies in the data. …”
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Preterm birth in low-middle income Countries
Published 2024“…Although the overall trend is decreasing, this is mainly in high-income countries (HIC). …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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Project Complexity, Project Managers’ Knowledge Creation Styles, and Project Performance
Published 2021“…The aim of this research is to find a generalized model of prediction and control of the project performance using the knowledge creation and considering the impact of project complexity on project performance. …”
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